Human Bone Disorder Reproduced In Mice

For the first time, scientists have re-created a unique human bone disease in a laboratory animal model. An international team of researchers at the National Institutes of Health and in Italy were able to remove cells from the bone marrow of patients with a genetic bone disorder, transplant the cells into mice, and grow human bone with the same type of abnormalities seen in the patients. The technique holds promise for creating animal models to study many forms of human bone disease, with the hope of discovering the underlying causes and developing novel treatments.

The success of the procedure, reported in the April 15th issue of The Journal of Clinical Investigation, lies in the special characteristics of cells in the bone marrow called stromal cells. The stromal cells have the unique ability to develop into a variety of tissues, including bone, cartilage, and the tissue framework that supports blood formation.

In previous studies, Dr. Pamela Gehron Robey and colleagues at the National Institute of Dental Research (NIDR) perfected a technique for using stromal cells to grow normal human bone in mice. Stromal cells taken from healthy human donors were grown in the laboratory, mixed with ceramic particles, then transplanted under the skin of immune-compromised mice, where they formed a capsule of new bone. The ceramic chips provided structural support for bone growth. The result was a replica of normal bone, consisting of areas of new bone formation surrounding a cavity of healthy marrow that has the cellular infrastructure needed to grow blood cells.

Dr. Gehron Robey, chief of NIDR's Craniofacial and Skeletal Diseases Branch, and Dr. Paolo Bianco, Professor of Pathology at the University of L'Aquila, Italy, coordinated an international research effort to adapt the principle of this technique to develop an animal model for a genetic disorder called McCune-Albright syndrome (MAS) starting from abnorm

Contact: Wayne Little
NIH/National Institute of Dental and Craniofacial Research

Page: 1 2 3

Related biology news :

1. Human chromosome 5 final sequence analysis released to public
2. Humans march to a faster genetic drummer than primates, UC Riverside research says
3. Applied Mathematical Models in Human Physiology
4. Human health risks in space flight focus of research internships
5. Human periodontal ligament stem cells isolated for the first time
6. Organization for Human Brain Mapping 2004 Annual Meeting
7. 20 May AAAS lecture: Computers that Respond to Human Emotion
8. Human brain works heavy statistics learning language
9. New Woods Hole Center for Oceans and Human Health established
10. European Society of Human Reproduction and Embryology conference - June 2004
11. Human genome-wide RNAi library for biotech and pharma research

Post Your Comments:

(Date:8/21/2020)... ... August 18, 2020 , ... Sentien ... announced that the U.S. Food and Drug Administration (FDA) has approved the company’s ... for the treatment of severe COVID-19. Approval of this IND allows Sentien to ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently ... ideal for public health agencies of all sizes. With a focus on tracking ... individuals find appropriate health care, Mosio helps public health departments automate communications and ...
(Date:7/31/2020)... (PRWEB) , ... July 30, 2020 , ... ... Research (SBIR) Phase II contract awarded by the Joint Science & Technology Office—Chemical ... this project is to develop, optimize, and scale-up a highly efficient mammalian cell ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... TORONTO (PRWEB) , ... July 29, 2020 , ... eSource ... and inefficiencies. This webinar will cover the history of eSource, the reasons it did ... From EMR/EHR to wearables, to site source, the industry is moving towards capturing data ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to ... Bioactives. “It’s the only technology of its kind on the market and we were ... with the protective capacity of traditional cultured ingredients, creating a natural way to extend ...
(Date:7/10/2020)... ... 09, 2020 , ... In most research using the zebrafish ... formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the ... using the zebrafish model to investigate the causes of leukaemia and its relationship ...
(Date:7/1/2020)... ... June 29, 2020 , ... The ... purchasing contracts to its membership, recently named BioFit Engineered Products an ... opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts at discounted ...
Breaking Biology Technology:
Cached News: