Human cancer-detection test showing promise in...( chell said. Telomerase activity appear...)

Human cancer-detection test showing promise in pets, too

chell said. Telomerase activity appears to be a unique feature of benign tumor cells that have undergone malignant transformation.

In a previous study of dogs, published in the same journal in 1998, Kitchell and colleagues reported that, in a study of tissue samples, 24 of 26 malignant tumors, one of four benign tumors and none of three normal tissues tested positive for telomerase activity. Of 46 fluid samples, 12 of 16 malignant and just one of 30 normal benign fluids showed signs of the enzymes activity.

Though we tested a small number of samples, the authors wrote in the cat study, we feel that the correlation of our results with histopathology is sufficient to warrant further research on the application of this assay as a diagnostic tool at institutions with the correct storage facilities. Authors of the recent cat study were Kitchell, Casey D. Cadile, Barbara J. Biller, Elizabeth R. Hetler and Rebecca Balkin. The Morris Animal Foundation provided partial funding for the research.

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Contact: Jim Barlow
b-james3@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
3-Dec-2001

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