HOME >> BIOLOGY >> NEWS
Human genome-wide RNAi library for biotech and pharma research

In a paper published this week in the journal Nature (March 25), scientists at Cold Spring Harbor Laboratory announced the creation of the first library of human RNA interference (RNAi) clones, which will eventually provide users the ability to shut off virtually every gene in the human genome. Based on a versatile and powerful method for triggering RNAi - short hairpin RNA (shRNA) - the library is the first DNA vector-based, human genome-wide RNAi library that is sequence verified.

Several leading pharmaceutical companies have entered into agreements with Long Island-based Cold Spring Harbor Laboratory (CSHL), to take advantage of the strong potential for therapeutic discovery that this powerful library promises to deliver. Licensing non-exclusive rights allows these companies to use the RNAi library for target identification and validation purposes.

"The beauty of the RNA interference phenomenon is its potential to shut off individual genes and only those genes," said Dr. Greg Hannon, lead scientist in the development of the new library. "By individually targeting more than 10,000 human genes through this sequence-based method, a wide variety of companies can rapidly identify and validate target genes that cause disease, and develop drugs to hit those targets."

RNA interference is sweeping the biotech world, because it provides researchers a convenient way to silence individual genes. A variety of methods exist for triggering RNAi. However, the short-hairpin (shRNA) method developed by Hannon and his colleagues is one of the most efficient and has been validated in a large number of studies with different animal and human cell cultures as well as in whole animals, where the method has been shown by Hannon's group to trigger stable, heritable gene silencing. In addition, the sequence-validated library of short hairpin RNA molecules targets each one of more than 10,000 different human genes in triplicate, i.e. with three
'"/>

Contact: Peter Sherwood
sherwood@cshl.edu
516-367-6947
Cold Spring Harbor Laboratory
26-Mar-2004


Page: 1 2

Related biology news :

1. Human chromosome 5 final sequence analysis released to public
2. Humans march to a faster genetic drummer than primates, UC Riverside research says
3. Applied Mathematical Models in Human Physiology
4. Human health risks in space flight focus of research internships
5. Human periodontal ligament stem cells isolated for the first time
6. Organization for Human Brain Mapping 2004 Annual Meeting
7. 20 May AAAS lecture: Computers that Respond to Human Emotion
8. Human brain works heavy statistics learning language
9. New Woods Hole Center for Oceans and Human Health established
10. European Society of Human Reproduction and Embryology conference - June 2004
11. Human genetic sampling

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... partners with the pharmaceutical and biotechnology industries to improve patient outcomes and quality ... Several trends in analytical testing are being attributed to new regulatory requirements for ...
(Date:10/11/2017)... USA (PRWEB) , ... October 11, 2017 , ... ComplianceOnline’s ... take place on 7th and 8th June 2018 in San Francisco, CA. The Summit ... as well as several distinguished CEOs, board directors and government officials from around the ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
Breaking Biology Technology:
Cached News: