HOME >> BIOLOGY >> NEWS
Human periodontal ligament stem cells isolated for the first time

Scientists at the National Institute of Dental and Craniofacial Research (NIDCR), one of the National Institutes of Health, and their colleagues have isolated human postnatal stem cells for the first time directly from the periodontal ligament, the fibrous, net-like tendon that holds our teeth in their sockets.

The scientists also say these cells have "tremendous potential" to regenerate the periodontal ligament, a common target of advanced gum (periodontal) disease. This enthusiasm is based on follow up experiments, in which the researchers implanted the human adult stem cells into rodents, and most of the cells differentiated into a mixture of periodontal ligament -including the specific fiber bundles that attach tooth to bone - and the mineralized tissue called cementum that covers the roots of our teeth.

"The stem cells produced beautifully dense, regenerated tissue in the animals," said Dr. Songtao Shi, a senior author on the paper and an NIDCR scientist. "That was when we knew they had great potential one day as a treatment for periodontal disease, and we're continuing to follow up on this promise with additional animal work." The results are published in the current issue of The Lancet.

Shi said scientists have suspected since the 1970s that the periodontal ligament might contain its own unique stem cells. But, for a variety of technical reasons, the search had come up empty, leaving some to wonder whether stem cells could be extracted from such a tiny bit of tissue known to contain a confusing mixture of cell types and subsets.

About two years ago, Shi said he and his colleagues decided to take a stab at the problem. They obtained 25 newly extracted third molars, or wisdom teeth, and gently tugged the ligament free from the root of the tooth. Through trial and error, the group successfully extracted, sorted, and cultured the various cells from the tissue, hoping they had isolated stem cells in one of their many P
'"/>

Contact: Bob Kuska
kuskar@nidcr.nih.gov
301-594-7560
NIH/National Institute of Dental and Craniofacial Research
8-Jul-2004


Page: 1 2 3

Related biology news :

1. Human chromosome 5 final sequence analysis released to public
2. Humans march to a faster genetic drummer than primates, UC Riverside research says
3. Applied Mathematical Models in Human Physiology
4. Human health risks in space flight focus of research internships
5. Organization for Human Brain Mapping 2004 Annual Meeting
6. 20 May AAAS lecture: Computers that Respond to Human Emotion
7. Human brain works heavy statistics learning language
8. New Woods Hole Center for Oceans and Human Health established
9. European Society of Human Reproduction and Embryology conference - June 2004
10. Human genome-wide RNAi library for biotech and pharma research
11. Human genetic sampling

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/22/2019)... (PRWEB) , ... October 21, 2019 , ... Join ... MS, Director of Bioanalytical in a live session on Thursday, October 31, ... CRO partner. , A good CRO partner should have expertise in method development, ...
(Date:10/17/2019)... (PRWEB) , ... October 15, 2019 , ... ... Prepared Media for the Microbiological Community”. , Microbiology International currently manufactures ready-to-use culture ... company also offers pre-poured agar plates & liquid supplements. , This major step ...
(Date:10/15/2019)... ... 2019 , ... Erchonia, the global leader in the manufacturing ... in Orlando & 18th Annual Golf Tournament. The invite-only, four-day event starts ... Melbourne. , The first day will kick off with training and roundtable discussions ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... Drug resistance has been declared ... Health Organization, with MRSA becoming one of the most serious concerns. Hong Kong cannot ... cases of community-associated MRSA (CA-MRSA), or a seven-fold of the figure in 2007 – ...
(Date:9/24/2019)... , ... September 24, 2019 , ... In the past ... research led by faculty at South Dakota School of Mines & Technology ... microbes that attach to surfaces to form a slimy and yet strong layer which ...
(Date:9/17/2019)... ... September 17, 2019 , ... Geneticure, Inc., a Rochester ... today that the U.S. Patent and Trademark Office (USPTO) and European Patent Office ... class recommendations for hypertension treatment. , The patent applies to Geneticure’s first ...
(Date:9/17/2019)... (PRWEB) , ... September 16, 2019 , ... ... was co-located with the China Focus @ Biotech Week Boston, a forum organized ... and collaborations in healthcare innovation. , After a careful process of evaluation, twelve ...
Breaking Biology Technology:
Cached News: