Hunt For Early Heart Attack Ge...( More than 2000 people will b...)

Hunt For Early Heart Attack Genes Begins

More than 2,000 people will be enrolled in a hunt for the genetic causes that underlie ?early? heart attacks that strike men and women in middle age. The study is part of the research program of the Starr Center for Human Genetics at The Rockefeller University in New York City.

"Finding the genes that contribute to heart attacks is the first step towards developing better methods for the prevention, early diagnosis and treatment for this disease that is single largest killer of American men and women," says Jan L. Breslow, M.D., head of The Rockefeller University's Laboratory of Biochemical Genetics and Metabolism and the immediate past-president of the American Heart Association (AHA).

Nearly 57.5 million Americans have one or more types of cardiovascular disease, which includes heart attacks, high blood pressure and stroke, according to the AHA. Heart attacks, which claimed more than 487,000 lives in 1994, cause one in every 4.7 American deaths. People younger than 65 account for 45 percent of heart attacks.

"We have good evidence that heart disease, including heart attacks, runs in families. Heart attacks result from a person's complex genetic makeup and his or her interactions with the environment including what he or she eats, how much he or she exercises and if he or she smokes. While we know a great deal about the influence of diet, exercise and cigarettes on heart disease, we do not yet know the identity of genes that would explain susceptibility to heart attacks," explains coinvestigator Elizabeth De Oliveira e Silva, M.D., research associate at Rockefeller.

To locate and determine the structure and function of one or more genes involved in heart attacks, the scientists will examine blood samples and medical histories of 2,000 people who have heart attacks at an early age. Because heart disease is likely to have various genetic causes, enrolling such a large study population will help the sci
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Contact: Marion E. Glick or Joseph Bonner
runews@rockvax.rockefeller.edu
212-327-7900
Rockefeller University
16-Sep-1997

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