Hutchinson Center researchers first to induce state of suspended animation in model vertebrate organism

s of abnormal cells, and only a subset are multiplying at any one time. The vast majority of cells in a tumor are in a state of low oxygen tension and are non-proliferating - which is the reason that some tumors don't respond to certain forms of radiation and chemotherapy." Most chemotherapeutic agents work by selectively killing actively dividing cells, meaning that many quiescent, or non-dividing, tumor cells are immune to treatment.

Suspended animation also has a role in the growth of normal cells, Roth said.

"Stem cells - like those that give rise to your skin - are self-renewing and have the capacity to reproduce at certain times in your life," he said. "Some of those cells might be dividing right now, while others withhold their proliferation potential until a later time. Lots of scientists are interested in how cells maintain this state of quiescence and then resume cell division." The phenomenon also is critical for the normal development of many animals.

"Numerous organisms have naturally occurring states of suspended animation," Roth said. "About 70 species of mammals alone do this as a way to increase reproductive fitness. For example, mice delay implantation of their embryos in the uterus while they are lactating. The embryos halt implantation - and any further development - until lactation stops."

Zebrafish in the wild haven't yet been observed to undergo suspended animation, but the metabolic shutdown that Roth induces in his laboratory resembles the reversible state of limbo that has been observed in nature in other organisms.

Roth and Padilla, the paper's co-author, compared the developmental capability of zebrafish embryos that had been exposed to normal atmospheric conditions to those grown in anoxic (oxygen-free) chambers. Absence of oxygen caused development to arrest and all observable metabolic activity to cease - including a shutdown of the heart, which normally beats 100 times per minute. The researchers found that embryos 25

Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Page: 1 2 3

Related biology news :

1. Intel and Fred Hutchinson to explore the use of nanotechnology tools for early disease detection
2. American Association for Cancer Research honors Fred Hutchinson Cancer Research Center investigator
3. Fred Hutchinson Cancer Research Center, University of Washington join in national effort to study health impact of toxic substances
4. Digging for genetic fossils: Hutchinson Center researchers solve structure of ancient biological molecule
5. Fred Hutchinson Cancer Research Center to lead international team to accelerate investigation of immune-related genes
6. Hutchinson Center researcher awarded Block lectureship
7. White House honors Hutchinson Center Scientist with Presidential Early Career Award
8. Hutchinson Center to lead $11.5 million ovarian-cancer research consortium
9. Fred Hutchinson Cancer Research Center researcher one of five awarded $1 million distinguished young scholars grant
10. Fred Hutchinson Cancer Research Center And Targeted Genetics Announces Issuance Of Braod Patent Covering Antigen-Specific T Cell Expansion
11. Hutchinson Center Director Wins Americas Nobel

Post Your Comments:

(Date:8/25/2019)... ... August 23, 2019 , ... BioInformatics, part of Science ... Experts-on-Demand. The service helps connect companies with a network of thousands of life ... technology, and medicine is moving faster than ever, and we have built a ...
(Date:8/21/2019)... ... August 21, 2019 , ... AbSci, a revolutionary ... and low-cost biomanufacturing of complex protein therapeutics, today announced the appointment of Fred ... Advisory Board, Dr. Larimore brings more than 30 years of experience in biopharmaceutical ...
(Date:8/21/2019)... Va. (PRWEB) , ... August 20, 2019 , ... ... customer experience for the second time since BioInformatics first fielded the survey in ... 2019: Life Science Customer Experience , from BioInformatics, part of Science and Medicine ...
Breaking Biology News(10 mins):
(Date:7/19/2019)... ... July 18, 2019 , ... ... investment to enlarge their current piezo motion facilities in Lederhose, Germany, increasing their ... for multilayer piezo ceramic assembly production in addition to general office space, a ...
(Date:7/17/2019)... ... July 16, 2019 , ... ... agreement for the development and manufacturing of Zolgensma® (onasemnogene abeparvovec-xioi), an AveXis ... AveXis, a Novartis company, will have dedicated manufacturing space at the new, ...
(Date:7/9/2019)... ... July 08, 2019 , ... Today, at the BIO World ... Corn Growers Association (NCGA) announced the winners of the Consider Corn Challenge II. ... process using field corn to produce biobased materials. , “Corn is a sustainable, ...
(Date:6/26/2019)... ... 26, 2019 , ... Alice Branton today released research results from preclinical trials ... Gluconate, which can prove to be beneficial for treating Hypomagnesemia. , The preclinical trial ... in crystallite size , Over 142% increase in particle size , ...
Breaking Biology Technology:
Cached News: