Project 4: Refining the use of cancer-screening tools - This study will evaluate
new and existing cancer biomarkers to determine how they can most effectively be
used to screen for ovarian cancer. One such biomarker is CA 125, a protein found
in the blood that in large amounts can signal the presence of ovarian cancer.
The conventional approach for screening with CA 125 is to consider the test
positive if the blood level exceeds 35 U/ml. However, this "one-size-fits-all
approach" isn't appropriate for all women, some of whom normally have a
consistently elevated CA 125 level. The aim of this project is to refine the use
of such biomarkers to determine which markers are most useful for which women.
The Consortium will also work with researchers at the NCI and in Britain to
design an international screening trial for post-menopausal women. Project
principal investigator: Martin McIntosh, Ph.D., research assistant p
Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center