HOME >> BIOLOGY >> NEWS
Hydroxyurea therapy improves survival in most severely affected sickle cell patients

-approved drug for the treatment of sickle cell anemia.

In the new long-term "observational" study, patients selected with their physicians whether to continue, start, or stop treatment with hydroxyurea. Seventy-five (25 percent) of the original 299 patients died during the 9-year study. According to study authors, this statistic reflects the severity of the disease as required by the study design, and the high death rate in adults with sickle cell anemia.

Among study participants, the death rate was 28 percent for those with the lowest fetal hemoglobin level compared to a 15 percent death rate for those with the highest level of fetal hemoglobin. Fetal hemoglobin inside red blood cells of sickle cell anemia patients may prevent these cells from becoming sickled and rigid, hallmarks of the inherited disease. Hydroxyurea is believed to stimulate the production of fetal hemoglobin.

The new study also found that patients with 3 or more painful episodes per year during the trial had a 27 percent death rate versus a 17 percent death rate for those with less frequent episodes.

"Hydroxyurea's ability to reduce complications in the sickest patients is strongly connected to lower death rates," said Duane Bonds, M.D., study co-author and project officer for the MSH Patients' Follow-up Study. "These results also confirm that the benefits of hydroxyurea persist. After the original trial ended, we didn't know if the benefits of the drug would be long term," added Bonds. The new study also has important implications for significantly decreasing health care costs, said Bonds. Patients with more severe forms of the disease are seen in the emergency room and are hospitalized more frequently than patients who are less severely affected.

According to lead investigator Dr. Martin Steinberg, who is Director of the Center of Excellence in Sickle Cell Disease at Boston University School of Medicine, the latest research has important implications for
'"/>

Contact: NHLBI Communications Office
301-496-4236
NIH/National Heart, Lung, and Blood Institute
1-Apr-2003


Page: 1 2 3

Related biology news :

1. Targeted therapy knocks out pediatric brain cancer in mice
2. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
3. Columbia research to examine gene influence on severity of peridontal disease, therapy response
4. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
5. The search for a kinder, gentler chemotherapy
6. Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
7. Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
8. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
9. Jefferson Lab detector technology aids development of cystic fibrosis therapy
10. Stroking up cellular therapy
11. Smart gene therapy protects against damage from heart attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
(Date:3/28/2017)... The report "Video Surveillance Market ... Storage Devices), Software (Video Analytics, VMS), and Service (VSaaS, ... to 2022", published by MarketsandMarkets, the market was valued ... to reach USD 75.64 Billion by 2022, at a ... year considered for the study is 2016 and the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that ... Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital Los ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/9/2017)... , ... October 09, 2017 , ... The award-winning American ... broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , ... faced with the challenge of how to continue to feed a growing nation. At ...
Breaking Biology Technology:
Cached News: