Hypoglycemia may affect newborn's brain cell function, says Hopkins researcher

Hypoglycemia, or low blood sugar, may have a significant effect on activity patterns in a newborn's brain, say researchers at Johns Hopkins Children's Center and St. Christopher's Hospital for Children in Philadelphia. Their study of piglet brains, which are metabolically and structurally close to that of humans, is reported in this month's Brain Research.

"While some researchers question whether hypoglycemia in infants has long-term detrimental health effects on the brain, we believe it does," says Children's Center neonatologist Jane McGowan, M.D., the paper's lead author. "Both learning and memory may be affected by any alteration of the ability of the brain to make synapses."

McGowan and her collaborators found that low blood sugar levels altered the ability of some neurotransmitter receptors to bind glutamate. These glutamate receptors are known to play an important role in the formation of synapses needed for normal brain function. McGowan suggests hypoglycemia and subsequent changes in the behavior of these glutamate receptors may affect the ability of the brain to develop normally. The causes of hypoglycemia in human infants are diverse, but it most often occurs because a mother is diabetic or if there is an interruption in the baby's own sugar storage processes.

The researchers studied two kinds of glutamate receptors, the kainate and N-methyl-D-aspartate (NMDA) receptors, so-called because each receptor specifically binds one of the two glutamate-like molecules. Kainate and NMDA are chemicals typically used to assess glutamate receptor activity in neurological experiments. Using a protocol approved by the Institutional Animal Care and Use Committee at MCP Hahnemann University, the research team sustained hypoglycemia in piglets (3 to 6 days old) for two hours with insulin injections. Researchers then extracted brain tissue from six hypoglycemic piglets and six piglets with normal blood sugar levels. After isolating brain cell membr

Contact: David Bricker
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. K-State, other universities to study how climate affects plant evolution
2. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
3. Anxiety during pregnancy affects child behavior
4. Hormone helps fish to mate, may affect human hearing
5. Moderate iron deficiency affects cognitive performance - but iron supplementation improves it
6. UCR study says second-hand smoke affects healing
7. How amphetamine affects the dopamine transporter
8. A link between thimerosal and the brain: Can vaccines affect central nervous system function?
9. Earliest evidence of humans affecting aquatic ecology in Canada, United States
10. Rutgers scientists discover protein in brain affects learning and memory
11. Social stress adversely affects digestive function in subordinate cichlid fish

Post Your Comments:

(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply ... a time. So which eye do you rinse first if a dangerous substance enters both ... Duo Eye Wash with its unique dual eye piece. , “Whether its dirt and ...
(Date:10/11/2017)... ... , ... Disappearing forests and increased emissions are the main causes of the ... Especially those living in larger cities are affected by air pollution related diseases. , ... pollution-affected countries globally - decided to take action. , “I knew I had to ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time ... US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. ... US2020. , US2020’s mission is to change the trajectory of STEM education in ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
Breaking Biology Technology:
Cached News: