HOME >> BIOLOGY >> NEWS
Hypoglycemia may affect newborn's brain cell function, says Hopkins researcher

Hypoglycemia, or low blood sugar, may have a significant effect on activity patterns in a newborn's brain, say researchers at Johns Hopkins Children's Center and St. Christopher's Hospital for Children in Philadelphia. Their study of piglet brains, which are metabolically and structurally close to that of humans, is reported in this month's Brain Research.

"While some researchers question whether hypoglycemia in infants has long-term detrimental health effects on the brain, we believe it does," says Children's Center neonatologist Jane McGowan, M.D., the paper's lead author. "Both learning and memory may be affected by any alteration of the ability of the brain to make synapses."

McGowan and her collaborators found that low blood sugar levels altered the ability of some neurotransmitter receptors to bind glutamate. These glutamate receptors are known to play an important role in the formation of synapses needed for normal brain function. McGowan suggests hypoglycemia and subsequent changes in the behavior of these glutamate receptors may affect the ability of the brain to develop normally. The causes of hypoglycemia in human infants are diverse, but it most often occurs because a mother is diabetic or if there is an interruption in the baby's own sugar storage processes.

The researchers studied two kinds of glutamate receptors, the kainate and N-methyl-D-aspartate (NMDA) receptors, so-called because each receptor specifically binds one of the two glutamate-like molecules. Kainate and NMDA are chemicals typically used to assess glutamate receptor activity in neurological experiments. Using a protocol approved by the Institutional Animal Care and Use Committee at MCP Hahnemann University, the research team sustained hypoglycemia in piglets (3 to 6 days old) for two hours with insulin injections. Researchers then extracted brain tissue from six hypoglycemic piglets and six piglets with normal blood sugar levels. After isolating brain cell membr
'"/>

Contact: David Bricker
dbricker@jhmi.edu
410-223-1728
Johns Hopkins Medical Institutions
14-Feb-2002


Page: 1 2

Related biology news :

1. K-State, other universities to study how climate affects plant evolution
2. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
3. Anxiety during pregnancy affects child behavior
4. Hormone helps fish to mate, may affect human hearing
5. Moderate iron deficiency affects cognitive performance - but iron supplementation improves it
6. UCR study says second-hand smoke affects healing
7. How amphetamine affects the dopamine transporter
8. A link between thimerosal and the brain: Can vaccines affect central nervous system function?
9. Earliest evidence of humans affecting aquatic ecology in Canada, United States
10. Rutgers scientists discover protein in brain affects learning and memory
11. Social stress adversely affects digestive function in subordinate cichlid fish

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back ... 8th June 2018 in San Francisco, CA. The Summit brings together current and former ... CEOs, board directors and government officials from around the world to address key issues ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
(Date:10/10/2017)... , ... October 10, 2017 , ... Dr. Bob Harman, ... his local San Diego Rotary Club. The event entitled “Stem Cells ... and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: