Hypoglycemia may affect newborn's brain cell function, says Hopkins researcher

Hypoglycemia, or low blood sugar, may have a significant effect on activity patterns in a newborn's brain, say researchers at Johns Hopkins Children's Center and St. Christopher's Hospital for Children in Philadelphia. Their study of piglet brains, which are metabolically and structurally close to that of humans, is reported in this month's Brain Research.

"While some researchers question whether hypoglycemia in infants has long-term detrimental health effects on the brain, we believe it does," says Children's Center neonatologist Jane McGowan, M.D., the paper's lead author. "Both learning and memory may be affected by any alteration of the ability of the brain to make synapses."

McGowan and her collaborators found that low blood sugar levels altered the ability of some neurotransmitter receptors to bind glutamate. These glutamate receptors are known to play an important role in the formation of synapses needed for normal brain function. McGowan suggests hypoglycemia and subsequent changes in the behavior of these glutamate receptors may affect the ability of the brain to develop normally. The causes of hypoglycemia in human infants are diverse, but it most often occurs because a mother is diabetic or if there is an interruption in the baby's own sugar storage processes.

The researchers studied two kinds of glutamate receptors, the kainate and N-methyl-D-aspartate (NMDA) receptors, so-called because each receptor specifically binds one of the two glutamate-like molecules. Kainate and NMDA are chemicals typically used to assess glutamate receptor activity in neurological experiments. Using a protocol approved by the Institutional Animal Care and Use Committee at MCP Hahnemann University, the research team sustained hypoglycemia in piglets (3 to 6 days old) for two hours with insulin injections. Researchers then extracted brain tissue from six hypoglycemic piglets and six piglets with normal blood sugar levels. After isolating brain cell membr

Contact: David Bricker
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. K-State, other universities to study how climate affects plant evolution
2. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
3. Anxiety during pregnancy affects child behavior
4. Hormone helps fish to mate, may affect human hearing
5. Moderate iron deficiency affects cognitive performance - but iron supplementation improves it
6. UCR study says second-hand smoke affects healing
7. How amphetamine affects the dopamine transporter
8. A link between thimerosal and the brain: Can vaccines affect central nervous system function?
9. Earliest evidence of humans affecting aquatic ecology in Canada, United States
10. Rutgers scientists discover protein in brain affects learning and memory
11. Social stress adversely affects digestive function in subordinate cichlid fish

Post Your Comments:

(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
(Date:4/5/2017)... April 5, 2017 Today HYPR Corp. ... the server component of the HYPR platform is officially ... the end-to-end security architecture that empowers biometric authentication across ... has already secured over 15 million users across the ... of connected home product suites and physical access represent ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  VMS BioMarketing, a leading provider of ... oncology Clinical Nurse Educator (CNE) network, which will launch this ... communication among health care professionals to enhance the patient care ... staff, and other health care professionals to help women who ... ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building ... corporate rebranding initiative announced today. The bold new look is part of a ... company moves into a significant growth period. , It will also expand its service ...
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North Carolina, ... Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the ...
Breaking Biology Technology:
Cached News: