HOME >> BIOLOGY >> NEWS
Identification of gene gives hope to children with progeria; May shed light on phenomenon of aging

[Boston, MA April 16, 2003] The Progeria Research Foundation (PRF), along with the National Institutes of Health (NIH), today announced the discovery of the gene that causes Hutchinson-Gilford Progeria Syndrome (HGPS or Progeria), a rare, fatal genetic condition characterized by an appearance of accelerated aging in children.

"Isolating the Progeria gene is a major achievement for the medical research community," said Francis Collins, MD, PhD, director, National Human Genome Research Institute and the senior author on the report, which appears today in Nature. "The discovery not only gives hope to children and families affected by Progeria, but also may shed light on the phenomenon of aging and cardiovascular disease."

Children with Progeria die from complications of cardiovascular disease or arteriosclerosis at an average age of 13. Researchers now believe finding the gene that causes Progeria may lead to answers surrounding the natural aging process and cardiovascular disease. Heart disease and stroke are the first and third leading causes of death in the United States, accounting for more than 40 percent of all deaths.

Within just one year of beginning the research, a group of leading scientists from the PRF Genetics Consortium were able to isolate the Progeria gene. Key aspects of the finding include the fact that Progeria is not inherited and that mutations to the gene LMNA (Lamin A) cause Progeria. The Lamin A protein is the structural scaffolding that holds the nucleus together and has been studied for years. Researchers now believe that the defective Lamin A protein makes the nucleus unstable. That cellular instability leads to the process of premature aging in Progeria.

In March 1999, Scott D. Berns, MD, MPH and Leslie Gordon, MD, PhD together with family, friends and colleagues formed the Progeria Research Foundation after their son Sam was diagnosed with Progeria at 21 months. They discovered a tremendous lack
'"/>

Contact: Liza Morris
lmorris@spectrumscience.com
202-355-6222
NIH/National Human Genome Research Institute
16-Apr-2003


Page: 1 2 3

Related biology news :

1. Identification of genes causing defects in vitamin B12 metabolism
2. Identification of the first gene in posttraumatic stress disorder
3. Comprehensive set of vision genes discovered: Identification could help in diagnosing and treating blinding diseases
4. Identification of genes may tell how plants recognize pollen
5. Identification of genes controlled by the weight-regulating hormone leptin may provide future targets for treating obesity
6. Scientists Invent Faster Gene Function Identification System
7. US investment firm gives away Rhode Island-sized lands in Chile
8. Small animal imaging gives cancer clues
9. Melting ice cap gives urgency to new census of marine life project in Arctic Ocean
10. Research gives hope to preemies and Crohns patients
11. Field Museum gives Parker/Gentry Award to Chinese conservationist

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/18/2018)... SAN DIEGO (PRWEB) , ... October 18, 2018 , ... ... difficult to avoid but needs to be identified and mitigated. Failure to recognize ... the target patient population, as well as a serious challenge to drug developers faced ...
(Date:10/18/2018)... ... October 18, 2018 , ... On June 11 of this year, ... gene-editing therapeutics to hold its collective breath. Two different research teams independently found ... p53 gene mutation. Mutations in the p53 gene have the distinction of being ...
(Date:10/17/2018)... ... October 17, 2018 , ... Maintenance of ... patients, say 65 percent of physicians surveyed by MDLinx, a medical news, information, ... of medical specialties revealed that many physicians are frustrated with the mandated MOC ...
Breaking Biology News(10 mins):
(Date:9/29/2018)... ... September 29, 2018 , ... Voxx Analytics announces the ... access the power of influence analytics and data-driven engagement decision making. , “For ... that didn’t necessarily have access to the same financial resources as our Top ...
(Date:9/27/2018)... ... September 26, 2018 , ... Consumers adopting new health care ... physicians, according to a new Zeldis Research and Schlesinger Group study, “The Consumerization ... consumer adoption of fitness and health wearables, remote monitoring, patient portals and other ...
(Date:9/27/2018)... BUDAPEST, Hungary and CAMBRIDGE, Mass. (PRWEB) , ... ... ... headquartered in Budapest with US offices in Cambridge, MA, announce today that Holotype ... customers or collaborators at the annual meeting of the American Society for Histocompatibility ...
(Date:9/22/2018)... ... September 21, 2018 , ... ... function, development, and pathogenesis requires tools that can rapidly and consistently quantify ... Ion Beam Imaging by Time-Of-Flight (MIBI-TOF) detects elements from hydrogen to uranium, ...
Breaking Biology Technology:
Cached News: