HOME >> BIOLOGY >> NEWS
Identification of genes causing defects in vitamin B12 metabolism

Montreal, December 10, 2002 Investigators at the University of Calgary and McGill University have identified genes that underlie two severe diseases of vitamin B12 metabolism. The two diseases, known as the cblA and cblB forms of methylmalonic aciduria, may produce brain damage, mental retardation and even death if not detected in infancy or early childhood.

Melissa Dobson, a graduate student at the University of Calgary working with Roy Gravel PhD in the Department of Biochemistry and Molecular Biology, is lead author of two papers reporting the identification of the two genes. The genes were first identified in bacteria and then traced to their human counterparts. She credits the human genome project with her breakthrough. "We can now compare human and bacterial DNA sequences to find human genes," states Dobson. "This was made possible by the availability of the sequence of the complete human genome."

To prove whether she and colleague Daniel Leclerc, PhD, had identified the correct genes, she approached her McGill collaborators, Dr. David Rosenblatt and Dr. Thomas Hudson, for help in screening patients. The McGill University Health Centre (MUHC) has a world-renowned diagnostic facility and cell bank for patients with genetic diseases involving vitamin B12. Using Genome Quebec's MUHC -based sequencing centre, Dobson and her colleagues confirmed the presence of mutations in DNA from patients with the two diseases.

"We have identified two different genes that are critical to the processing of vitamin B12 by finding mutations in patients who have particular forms of methylmalonic aciduria," according to Dobson. Methylmalonic acid is a chemical intermediate in the breakdown of proteins and other substances. It accumulates in the body and is excreted in large amounts in the urine because the blocks in the processing of vitamin B12 prevent its metabolism.

Identifying the genes that cause cblA and cblB represents a landmark breakthro
'"/>

Contact: Christine Zeindler
christine.zeindler@muhc.mcgill.ca
514-934-1934
McGill University
10-Dec-2002


Page: 1 2

Related biology news :

1. Identification of gene gives hope to children with progeria; May shed light on phenomenon of aging
2. Identification of the first gene in posttraumatic stress disorder
3. Comprehensive set of vision genes discovered: Identification could help in diagnosing and treating blinding diseases
4. Identification of genes may tell how plants recognize pollen
5. Identification of genes controlled by the weight-regulating hormone leptin may provide future targets for treating obesity
6. Scientists Invent Faster Gene Function Identification System
7. Belgian researchers explore revolutionary approach to angiogenesis
8. Tracing genes, biologists show lizard migration is traced to Florida
9. Certain genes boost fish oils protection against breast cancer
10. Fossil genes reveal how life sheds form and function
11. Missing genes may help explain why plague bacteria are so deadly

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2019)... ... 2019 , ... MMJ International Holdings, the premier medical cannabis ... trials and research, announced that it is seeking fast track designation approval from ... the review and approval of drugs in development that treat serious or life ...
(Date:2/11/2019)... ... February 11, 2019 , ... ... services, announced a new forensic genealogy service offering to law enforcement investigators and ... testing and genealogy to develop ancestral relationships between samples and deliver leads to ...
(Date:2/6/2019)... ... February 05, 2019 , ... Amino Labs, ... partnered with MindFuel, a leading organization in educational science, technology, engineering and math ... Labs has pioneered a syn-bio starter kit for teachers – the Amino ...
Breaking Biology News(10 mins):
(Date:2/14/2019)... N.J. (PRWEB) , ... February 14, 2019 , ... ... provider of helium based leak testing systems for the pharmaceutical, biotechnology and food ... the company moving forward. Brian Mulhall has been named Chief Executive ...
(Date:2/6/2019)... ... February 05, 2019 , ... Firmex ... executive management team to acquire Firmex, one of the fastest-growing and most widely-used ... Montreal-based private equity firm. Debt financing was provided by the Bank of Montreal. ...
(Date:2/2/2019)... POMONA, Calif. (PRWEB) , ... January 31, 2019 , ... ... in food sciences as it hosts the Nuriv 2019 Expo West Music and Tech ... With a mission to foster innovation in the natural foods, beverages, and dietary supplement ...
(Date:2/2/2019)... NANTES, France (PRWEB) , ... February 01, 2019 ... ... technologies, is pleased to announce the appointment of its new CEO, Julien Dert, ... has 25 years of international experience in finance and management, in which more ...
Breaking Biology Technology:
Cached News: