HOME >> BIOLOGY >> NEWS
Identification of genes controlled by the weight-regulating hormone leptin may provide future targets for treating obesity

In an article in the April 15 issue of the journal Genes & Development, Jeffrey M. Friedman, Investigator of the Howard Hughes Medical Institute, and his team at The Rockefeller University, provide clues as to how a hormone that regulates body weight works. By scanning thousands of genes from obese mice, they discovered a group of genes that are specifically regulated by the hormone leptin. Obesity is a major health concern in the US. In this country alone, one in five adults suffer from obesity. Studies on how leptin works to control body weight could provide therapeutic targets in the battle of the bulge.

Leptin is produced by fat tissue and secreted into the bloodstream, working its way to the brain and other tissues where it carries out its job by sending a message to stop eating and to burn more fat. Mice that lack leptin are obese, weighing nearly three times more than their normal counterparts. When these obese mice are given hormone treatments, they lose weight in part because they eat less but there is another component to their weight loss that is not known.

To discover why leptin causes additional weight loss, Friedman and colleagues used oligonucleotide microarrays, popularly known as 'gene chips'. These tiny chips, containing thousands of gene fragments, are bathed in a solution containing messenger RNA from two different sources. In this instance, samples were taken from normal mice and mice with little or no natural leptin, after they were treated with the hormone. After mice lacking leptin were given the hormone, their fat cells changed the profile of gene expression in a distinct way, indicating that at least part of the effects of leptin are due to a regulation of gene expression. Many genes appeared that were known to be regulated by a protein named SREBP-1, including SREBP-1 itself. SREBP-1 is known to play a role in controlling fatty acid synthesis. In addition to SREBP-1, other genes involved in fatty acid synthesis were identified
'"/>

Contact: Joseph Bonner
bonnerj@rockvax.rockefeller.edu
212-327-8998
Cold Spring Harbor Laboratory
11-Apr-2000


Page: 1 2

Related biology news :

1. Identification of gene gives hope to children with progeria; May shed light on phenomenon of aging
2. Identification of genes causing defects in vitamin B12 metabolism
3. Identification of the first gene in posttraumatic stress disorder
4. Comprehensive set of vision genes discovered: Identification could help in diagnosing and treating blinding diseases
5. Identification of genes may tell how plants recognize pollen
6. Scientists Invent Faster Gene Function Identification System
7. Belgian researchers explore revolutionary approach to angiogenesis
8. Tracing genes, biologists show lizard migration is traced to Florida
9. Certain genes boost fish oils protection against breast cancer
10. Fossil genes reveal how life sheds form and function
11. Missing genes may help explain why plague bacteria are so deadly

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/10/2018)... , ... December 10, 2018 , ... ... strategic alliance to advance their shared goal of accelerating the development of the ... scale-up bioprocess systems to TRT’s core technology around human umbilical cord perivascular cells ...
(Date:12/5/2018)... ... December 03, 2018 , ... Quanta System announced ... in the distribution and marketing of cutting-edge aesthetic devices in the US. Since ... for 2018. Cartessa’s success can be attributed in-part to the company’s independent ...
(Date:12/5/2018)... ... December 04, 2018 , ... The new program ... the development of innovative solutions for which high-speed imaging is a necessary albeit ... to industrial machinery and instrumentation, allowing partner companies to dedicate their resources on ...
Breaking Biology News(10 mins):
(Date:11/26/2018)... ... November 26, 2018 , ... USARAD ... Healthineers and Omphalos Venture Partners (Virtual Radiologic founders) among other healthcare investors exhibits ... 25-29 at McCormick Place in Chicago. The company is proud to announce a ...
(Date:11/15/2018)... ... 2018 , ... Hüpnos announces the launch of ... It is estimated that 90 million Americans suffer from persistent snoring, ... resulting daytime fatigue causes extreme difficulty with concentration, focus and memory. It’s ...
(Date:11/13/2018)... CLARA, Calif. (PRWEB) , ... November 13, 2018 , ... ... its Beijing Office in China. With the increasingly growing demand for AFM technology in ... research and industrial communities by opening an office in Beijing equipped with Park AFM. ...
(Date:11/9/2018)... ... November 08, 2018 , ... Superior Controls, Inc. ... solutions with 140 employees on both the east and west coasts, today announced ... Convention Center on November 14 and 15 in Philadelphia. The event is hosted ...
Breaking Biology Technology:
Cached News: