HOME >> BIOLOGY >> NEWS
Identifying cancer genes Will it really lead to better treatment?

Copenhagen, Denmark: A systematic trawl through the human genome looking for the abnormalities that drive cancer is already producing promising results, a scientist told ECCO 12 The European Cancer Conference in Copenhagen today (Tuesday 23 September). Dr. Michael Stratton, Director of the Cancer Genome Project at the Wellcome Trust Sanger Institute, Cambridge, UK, described how his study of the BRAF mutation could provide new targets for drug development, which could lead to better targeted or even individualised - treatment for cancer patients.

The decoding of the human genome has allowed scientists to compare the normal DNA sequence with that seen in cancers, and hence identify abnormalities. The BRAF mutation is implicated in a number of common cancers, according to Dr. Stratton. It appears to be involved in the switching mechanism of the gene, and is found in 70% of melanomas, in 30% of some types of thyroid and ovarian cancer, and in 10% of colorectal tumours. Over 80% of the mutations bring about a single change in an amino acid, making it a relatively simple target for rectification. "Once we can identify this kind of abnormal biological process", said Dr. Stratton. "we can move on to the next stage developing drugs to prevent or correct it."

The traditional approach to research in cancer has been the comparison of treatments through randomised clinical trials, with the extrapolation of an average benefit to the individual. This often means that many patients are inefficiently treated, while only a few benefit. Gene targets herald a different approach, and are becoming increasingly important in the search for effective cancer treatments. Genes are implicated in cancer in a number of ways as oncogenes, which drive cancer forward, as tumour suppressor genes that slow down cell division, and as DNA repair genes, which help to keep chromosomes intact when genetic mutation occurs.

A small number of drugs targeted at mutated
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
45-3252-4179
Federation of European Cancer Societies
23-Sep-2003


Page: 1 2

Related biology news :

1. Identifying tick genes could halt disease, bioterrorism threat
2. Identifying individuals at risk for Alzheimers disease
3. Identifying novel small RNAs
4. Breakthrough in genomic technology: Identifying the biologically relevant parts of the human genome
5. Leader in cancer treatment and prevention research honored
6. International study findings link acne-like rash to effectiveness of new targeted cancer treatment
7. Chemical derived from vitamin-E shows early promise as cancer drug
8. New molecular link key to cellular proteins involved in cancer progression, other diseases
9. Phase II trials of second-generation antisense cancer drug planned following successful early study
10. Trial shows which brain cancer patients benefit from temozolomide
11. Genetic differences might help distinguish thyroid cancers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: