HOME >> BIOLOGY >> NEWS
Identifying novel small RNAs

Researchers have more than doubled the number of identified sRNAs in E. coli

Small RNAs (sRNAs) are important regulatory molecules found in both prokaryotic and eukaryotic cells. Although hundreds of sRNAs are found in eukaryotic cells, only thirteen have been identified in E. coli.

A highly anticipated paper in G&D will add seventeen previously unidentified sRNAs to this list, and provide a starting point for resolving an intriguing biological debate.

Unlike most RNA transcripts which encode proteins, sRNAs are non-coding transcripts they function directly as RNAs. Eukaryotic sRNAs are largely involved in ribosomal RNA processing and modification. Previously identified prokaryotic sRNAs are involved in a number of cellular processes, but none of which involve ribosomal RNA biogenesis.

This apparent difference between eukaryotic and prokaryotic sRNA functionality has prompted biologists to question whether this difference represents an evolutionary divergence or simply our incomplete knowledge of the full range of prokaryotic sRNA actions.

Dr. Susan Gottesman and colleagues at the National Institutes of Health have developed a systematic method to predict and identify novel sRNAs in the fully sequenced E. coli genome.

As previous genomic screens have overlooked these small non-coding sequences, Dr. Gottesman and colleagues utilized a multifaceted search strategy. By combining comparative genomics, RNA transcript analysis, microarray data and binding activity, the research team was able to minimize oversights and maximize yield.

As published in the July 1 issue of Genes & Development, Dr. Gottesman and colleagues have identified seventeen novel prokaryotic sRNAs. Their experimental methodology serves as a blueprint for the systematic identification of sRNAs in other organisms with sequenced genomes.

Furthermore, the functional characterization of these newly identified sRNAs will lend valuable
'"/>

Contact: Nora Popptio
poppito@cshl.org
Please e-mail
Cold Spring Harbor Laboratory
30-Jun-2001


Page: 1 2

Related biology news :

1. Identifying tick genes could halt disease, bioterrorism threat
2. Identifying cancer genes Will it really lead to better treatment?
3. Identifying individuals at risk for Alzheimers disease
4. Breakthrough in genomic technology: Identifying the biologically relevant parts of the human genome
5. A novel, safer strategy for regulating gene expression
6. European common frog found to use novel mating strategy
7. A liking for sweets, combined with novelty seeking, may predict alcoholism
8. Penn scientists identify novel pathway in aneurysms
9. UNC research accelerates discovery of novel gene function
10. Japanese researchers develop novel method of introducing transgenes into animals
11. Lupus Research Institute awards $3 million in novel research grants to further new science in lupus

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: