HOME >> BIOLOGY >> NEWS
Idun develops new drug screen for treatments of stroke, heart attack, and cancer

Key apoptosis reaction adaptable to high throughput screening

KEYSTONE, Colorado, January 22, 2001 - Idun Pharmaceuticals, Inc. described the successful recreation in the lab of a key biological reaction that occurs in human cells and is part of the apoptosis pathway. This assay is being used to help understand the mechanism of apoptosis at the molecular level and to screen new drugs that modulate apoptosis. This development was presented at the Molecular Mechanisms of Apoptosis Meeting in Keystone, Colorado.

In the study, entitled, Reconstitution of Apaf-4/Procaspase-9 Holoenzyme-Mediated Procaspase-3 Activation: Requirement for Caspase-9 Conformational Change or Apaf-1 Association, it was shown that recombinant components of the human apoptosis pathway can be combined in vitro to carry out the activation of one of the key components that triggers programmed cell death.

Developing a key apoptosis reaction in vitro that mimics a natural in vivo reaction has important applications, both for use as a drug screen and as a tool to better understand how apoptosis is regulated, said Dr. Kevin Tomaselli, Vice President, Discovery Research and Co-Founder of Idun Pharmaceuticals. This gives us the ability to screen for drugs in a high throughput format that modulate apoptosis by affecting this specific apoptosis reaction.

Iduns expertise and success in apoptosis encompasses the entire breadth of cutting edge biotechnology, said Steven Mento, Ph.D., President and CEO of Idun Pharmaceuticals. We bring together the disciplines of gene discovery, functional genomics, high throughput screening (HTS), biochemical validation, structural modeling, and targeted drug development and apply them to the discovery and characterization of human apoptosis genes. This includes determining the function of the genes and their role in disease. Based on that, we develop new drugs to treat important human diseases such as cancer, heart attacks and stroke. N
'"/>

Contact: Lora Pike
l.pike@noonanrusso.com
415-677-4455 ext.211
Noonan/Russo Communications
21-Jan-2001


Page: 1 2

Related biology news :

1. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
2. Carnegie Mellon U. develops microgel to recover enzymes for manufacturing, research assays
3. Scientists findings may lead to better understanding of how that sleep develops, matures
4. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
5. US develops lethal new viruses
6. Brookhaven Lab develops ThraxVac to clean up anthrax
7. Carnegie Mellon develops new process for growing bone
8. Cancer could be caught before it develops
9. St. Jude develops vaccine against potential pandemic influenza virus H5N1 using reverse genetics
10. University of Ulster develops DNA fingerprint techniques to fight bio-terrorism
11. Clothing from Corn: DuPont develops innovative process to create polymer from renewable resources

Post Your Comments:
(Date:5/7/2015)... , May 7, 2015 ... fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest touch ... FPC1035 are mainly considered for integration on the ... gives smartphone OEMs increased possibilities to integrate touch ... decreased size also improves possibilities for module manufacturers ...
(Date:4/27/2015)... 27, 2015 Profile Solutions, Inc. (OTC: PSIQ), ... systems is pleased to announce that Dr Gerry ... and member of its scientific advisory board. ... a thought leader in technology-enhanced learning models. He was ... has published studies and books focused on online student ...
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
(Date:5/27/2015)... 2015 Research and Markets ( ... Jain PharmaBiotech,s new report "Molecular Diagnostics ... their offering. This report describes ... will play an important role in practice ... and biological warfare in the 21st century. ...
(Date:5/27/2015)...  Tikcro Technologies Ltd. (OTCQB: TIKRF) today reported results ... Aviv Boim , CEO of Tikcro ... generate functional specific antibodies, targeting identified cancer immune checkpoints. ... by the development progress. We are excited to invest ... immune checkpoints gain clinical acceptance for cancer treatment."Net loss ...
(Date:5/27/2015)... 2015  Two years after its founding by a ... scientists, Oakland -based Counter Culture Labs ... mission to democratize science through a full-fledged community laboratory ... Photo - http://photos.prnewswire.com/prnh/20150526/218366LOGO ... Based out of the new Omni Commons ...
(Date:5/27/2015)... 2015 ­ Caris Life Sciences®, a leading ... medicine, today announced it has appointed the Levine Cancer ... excellence site in the Caris Centers of Excellence for ... Institute is one of the largest cancer care providers ... cancer patients annually. Derek Raghavan , M.D., Ph.D., ...
Breaking Biology Technology:Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 2Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 3Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 2East Bay's Counter Culture Labs Seeks to Open Doors of Science to Public 3Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 2Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 3Caris Life Sciences Designates Levine Cancer Institute as a Caris Center of Excellence 4
Cached News: