HOME >> BIOLOGY >> NEWS
Idun develops new drug screen for treatments of stroke, heart attack, and cancer

Key apoptosis reaction adaptable to high throughput screening

KEYSTONE, Colorado, January 22, 2001 - Idun Pharmaceuticals, Inc. described the successful recreation in the lab of a key biological reaction that occurs in human cells and is part of the apoptosis pathway. This assay is being used to help understand the mechanism of apoptosis at the molecular level and to screen new drugs that modulate apoptosis. This development was presented at the Molecular Mechanisms of Apoptosis Meeting in Keystone, Colorado.

In the study, entitled, Reconstitution of Apaf-4/Procaspase-9 Holoenzyme-Mediated Procaspase-3 Activation: Requirement for Caspase-9 Conformational Change or Apaf-1 Association, it was shown that recombinant components of the human apoptosis pathway can be combined in vitro to carry out the activation of one of the key components that triggers programmed cell death.

Developing a key apoptosis reaction in vitro that mimics a natural in vivo reaction has important applications, both for use as a drug screen and as a tool to better understand how apoptosis is regulated, said Dr. Kevin Tomaselli, Vice President, Discovery Research and Co-Founder of Idun Pharmaceuticals. This gives us the ability to screen for drugs in a high throughput format that modulate apoptosis by affecting this specific apoptosis reaction.

Iduns expertise and success in apoptosis encompasses the entire breadth of cutting edge biotechnology, said Steven Mento, Ph.D., President and CEO of Idun Pharmaceuticals. We bring together the disciplines of gene discovery, functional genomics, high throughput screening (HTS), biochemical validation, structural modeling, and targeted drug development and apply them to the discovery and characterization of human apoptosis genes. This includes determining the function of the genes and their role in disease. Based on that, we develop new drugs to treat important human diseases such as cancer, heart attacks and stroke. N
'"/>

Contact: Lora Pike
l.pike@noonanrusso.com
415-677-4455 ext.211
Noonan/Russo Communications
21-Jan-2001


Page: 1 2

Related biology news :

1. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
2. Carnegie Mellon U. develops microgel to recover enzymes for manufacturing, research assays
3. Scientists findings may lead to better understanding of how that sleep develops, matures
4. Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
5. US develops lethal new viruses
6. Brookhaven Lab develops ThraxVac to clean up anthrax
7. Carnegie Mellon develops new process for growing bone
8. Cancer could be caught before it develops
9. St. Jude develops vaccine against potential pandemic influenza virus H5N1 using reverse genetics
10. University of Ulster develops DNA fingerprint techniques to fight bio-terrorism
11. Clothing from Corn: DuPont develops innovative process to create polymer from renewable resources

Post Your Comments:
(Date:8/28/2014)... Bethesda, MD FASEB MARC (Maximizing Access to Research ... the American Society of Human Genetics from October 18 ... awards are meant to promote the entry of students, ... mainstream of the basic science community and to encourage ... of Human Genetics. This year MARC conferred 16 ...
(Date:8/28/2014)... groups and clinicians is critical to the development ... of Georgia research. , A qualitative study of ... that role models for successful breastfeeding help positively ... "Mothers who received that support are more likely ... Alex Anderson, an associate professor in the College ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
(Date:8/28/2014)... SPIE Fellow Glenn Boreman, Professor and ... and Director of the Center for Optoelectronics and Optical ... and co-founder and Chairman of the Board of Plasmonics, ... Vice President of SPIE, the international society for optics ... recent election results at the Annual General Meeting of ...
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)... Sterlitech is proud to announce that ... stable of products . These additional products ... include membrane filters with surface charges. , ... for our membrane process testing equipment, and correspondingly, a ... membranes,” explains Sterlitech President Mark Spatz. “The addition ...
Breaking Biology Technology:Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
Cached News: