HOME >> BIOLOGY >> NEWS
Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets

A unique tail at one end of a protein called Ubc12 stabilizes a molecular workshop that assembles the "on-switch cells" used to accelerate cell replication. This finding, by investigators at St. Jude Children's Research Hospital, is published online by the journal Nature Structual and Molecular Biology (NSMB).

The discovery of the exact structure of the tail and its role in cell replication holds promise that researchers can develop new types of drugs targeting the tail or the workshop itself, turning off the unrestrained multiplication of cancer cells.

The study also shows that a slight change in a structure common among many enzymes performing similar jobs can create a new enzyme with a unique activity.

The St. Jude researchers report that the stabilizing influence of Ubc12's protein tail is based on its ability to nestle within a groove of the larger molecule called APPBP1-UBA3. These two proteins, also known by the shorthand designation of E2 (Ubc12) and E1 (APPBP1-UBA3), cooperate with each other to form a workshop where the "on switch" that accelerates cell replication is cobbled together.

The workshop makes the switch by linking a tag called NEDD8 with its "target" a molecule called Cul1. NEDD8 then modifies Cul1, causing it to set off a cascade of biochemical reactions that eliminates the molecular brake controlling cell replication. In the absence of this brake, cell replication accelerates, and if left unchecked, could cause cancer.

Until now, the function of the E2 tail was unknown, according to Brenda Schulman, Ph.D., an assistant member of the St. Jude Genetics and Tumor Cell Biology and Structural Biology departments. Schulman is senior author of the NSMB report.

The current study shows that the tail of E2 plays a crucial role in a series of hand-offs in which NEDD8 passes from one enzyme to another. First, E2's tail helps E2 clamp onto E1. That allows E1 to activate NEDD8 through a process called adenylation (putting a
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
13-Sep-2004


Page: 1 2 3 4

Related biology news :

1. Images reveal how rotavirus - leading cause of diarrhea - enters cells
2. Images reveal how body regulates salt uptake in cells
3. Images of evolution
4. Images of enzyme suggest way to improve DNA sequencing
5. Laser Microscope At Cornell Images Serotonin In Live Cells
6. New molecular link key to cellular proteins involved in cancer progression, other diseases
7. Researchers identify protein promoting vascular tumor growth
8. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
9. Experimental drug shown to block mutant protein causing blood disease
10. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
11. New dye directly reveals activated proteins in living cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... States multicenter, prospective clinical study that demonstrates the accuracy of the FebriDx® ... identifying clinically significant acute bacterial and viral respiratory tract infections by testing ...
(Date:10/12/2017)... ... 12, 2017 , ... AMRI, a global contract research, development ... patient outcomes and quality of life, will now be offering its impurity solutions ... new regulatory requirements for all new drug products, including the finalization of ICH ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief ... ), Inc. has been selected for membership in ARCS Alumni Hall of ...
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
Breaking Biology Technology:
Cached News: