Images reveal how rotavirus - leading cause of diarrhea - enters cells

High-resolution images constructed by researchers at Children's Hospital Boston (CHB) and Harvard Medical School (HMS) reveal the molecular rearrangements that rotavirus the most common cause of severe, dehydrating diarrhea and vomiting in children worldwide uses to break into cells.

The work, published in the August 26th edition of Nature, is a major advance in the understanding of how viruses cause infection, and illustrates how vaccine development can be made "smarter" by probing the physical architecture of viruses and finding the minimum parts needed to prime the immune system, without having to use a whole virus to make a vaccine. The researchers are now collaborating with several other institutions to develop a vaccine based on their discoveries.

Rotavirus infects almost all children, usually between 6 months and 2 years of age, and causes gastroenteritis that is sometimes severe enough to require hospitalization. The virus kills about 440,000 children each year, mainly in developing countries. The only licensed vaccine, RotaShield, was pulled from the U.S. market in 1999 because of reported cases of intestinal intussusception (a condition causing bowel obstruction).

Led by Dr. Philip Dormitzer, a physician and structural virologist in CHB's Laboratory of Molecular Medicine, the researchers used crystallography and electron microscopy to determine the geometric structure and working parts of one of the virus's surface proteins, called VP4.

Rotavirus itself is a large, soccer ball-shaped, 20-sided particle with three layers.

"The outside layer is like a landing apparatus and is stripped off in the course of entry," explains Dormitzer, who also is an assistant professor of Pediatrics at HMS and is affiliated with HMS's Center for Molecular and Cellular Dynamics. "Its job is to get the innermost portions the genes and the replication machinery -- inside the cell."

From the outer layer project 60 "spi

Contact: Mary-Ellen Shay
Children's Hospital Boston

Page: 1 2 3

Related biology news :

1. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
2. Images reveal how body regulates salt uptake in cells
3. Images of evolution
4. Images of enzyme suggest way to improve DNA sequencing
5. Laser Microscope At Cornell Images Serotonin In Live Cells
6. DNA lends scientists a hand, revealing new chemical reactions
7. Award winning researchers reveal potential new role for Glivec
8. Hidden diversity: DNA barcoding reveals a common butterfly is actually 10 different species
9. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
10. Brown research reveals key insight into memory-making
11. Study reveals why eyes in some paintings seem to follow viewers

Post Your Comments:

(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval from the Centers ... making them the first Wharton’s jelly allografts to be assigned a Q code and ... are the first Wharton’s jelly allograft product to be recognized as a 361 HCT/P ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... Phase II contract awarded by the Joint Science & Technology Office—Chemical and Biological ... is to develop, optimize, and scale-up a highly efficient mammalian cell culture-based bioprocess ...
(Date:7/22/2020)... (PRWEB) , ... July 21, 2020 , ... ... digital transformation and innovation in technology and compliance, announces a new solution to ... companies must ensure every layer of their technology stack complies with FDA and ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
(Date:7/18/2020)... ... 16, 2020 , ... “We are thrilled to deliver this new technology to ... of its kind on the market and we were pleased that the IFT jury ... traditional cultured ingredients, creating a natural way to extend the shelf life and improve ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license to ... move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced ... Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the ... awards program, highlighting outstanding examples of how technology innovations and strategic initiatives can ...
Breaking Biology Technology:
Cached News: