HOME >> BIOLOGY >> NEWS
Images reveal how rotavirus - leading cause of diarrhea - enters cells

High-resolution images constructed by researchers at Children's Hospital Boston (CHB) and Harvard Medical School (HMS) reveal the molecular rearrangements that rotavirus the most common cause of severe, dehydrating diarrhea and vomiting in children worldwide uses to break into cells.

The work, published in the August 26th edition of Nature, is a major advance in the understanding of how viruses cause infection, and illustrates how vaccine development can be made "smarter" by probing the physical architecture of viruses and finding the minimum parts needed to prime the immune system, without having to use a whole virus to make a vaccine. The researchers are now collaborating with several other institutions to develop a vaccine based on their discoveries.

Rotavirus infects almost all children, usually between 6 months and 2 years of age, and causes gastroenteritis that is sometimes severe enough to require hospitalization. The virus kills about 440,000 children each year, mainly in developing countries. The only licensed vaccine, RotaShield, was pulled from the U.S. market in 1999 because of reported cases of intestinal intussusception (a condition causing bowel obstruction).

Led by Dr. Philip Dormitzer, a physician and structural virologist in CHB's Laboratory of Molecular Medicine, the researchers used crystallography and electron microscopy to determine the geometric structure and working parts of one of the virus's surface proteins, called VP4.

Rotavirus itself is a large, soccer ball-shaped, 20-sided particle with three layers.

"The outside layer is like a landing apparatus and is stripped off in the course of entry," explains Dormitzer, who also is an assistant professor of Pediatrics at HMS and is affiliated with HMS's Center for Molecular and Cellular Dynamics. "Its job is to get the innermost portions the genes and the replication machinery -- inside the cell."

From the outer layer project 60 "spi
'"/>

Contact: Mary-Ellen Shay
mary.shay@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
25-Aug-2004


Page: 1 2 3

Related biology news :

1. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
2. Images reveal how body regulates salt uptake in cells
3. Images of evolution
4. Images of enzyme suggest way to improve DNA sequencing
5. Laser Microscope At Cornell Images Serotonin In Live Cells
6. DNA lends scientists a hand, revealing new chemical reactions
7. Award winning researchers reveal potential new role for Glivec
8. Hidden diversity: DNA barcoding reveals a common butterfly is actually 10 different species
9. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
10. Brown research reveals key insight into memory-making
11. Study reveals why eyes in some paintings seem to follow viewers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... ... gene-to-protein and monoclonal antibody development services, today announced that the company has ... services to the pharmaceutical, diagnostics, and research industries. The decision to pursue ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around ... the use of mass spectrometry in this field has gained a lot of momentum ... choose which approach to use (LBA or MS)?” In many cases, either technology ...
(Date:6/23/2020)... ... , ... In its June 22 online post, business and technology news platform ... Ph.D., founder and director of stem cell biotechnology company Asymmetrex . Superb Crew ... starting July 5 it would begin offering free tissue stem cell counting ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
(Date:7/1/2020)... ... June 30, 2020 , ... Flagship ... of a new clinical diagnostics immuno-oncology service, TissueInsight . TissueInsight provides ... “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and immunologists in ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
(Date:6/23/2020)... Fla. (PRWEB) , ... June 23, 2020 , ... ... enabled solutions in complex indoor environments, announced today that Derek Fournier has been ... role of Chairman of the Board, effective immediately. , “DeCurtis Corporation has ...
Breaking Biology Technology:
Cached News: