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Images reveal how rotavirus - leading cause of diarrhea - enters cells

and easy and relatively cheap to produce, Dormitzer says; he believes the same is true of the "body." A vaccine based on these proteins could be very practical, especially for developing countries where rotavirus causes the most serious illness.

The team's findings may also shed light on how other so-called "non-enveloped" viruses--which lack a fatty outer membrane enter cells. These viruses include papillomavirus, adenovirus, and rhinovirus. Entry mechanisms for viruses with outer envelopes are much better understood, says Dormitzer.


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Contact: Mary-Ellen Shay
mary.shay@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
25-Aug-2004


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