HOME >> BIOLOGY >> NEWS
Immune Response To Hepatitis B Spares Liver Cells

A new study suggests that, contrary to current belief, the immune system eliminates most hepatitis B virus (HBV) without resorting to large-scale destruction of infected liver cells. A report of the study, conducted by National Institute of Allergy and Infectious Diseases (NIAID) grantees and scientists, appears in the April 30, 1999, issue of Science.

"This is an intriguing finding," notes NIAID Director Anthony S. Fauci, M.D. "By advancing our understanding of how HBV is cleared from the liver, it could lead to better treatments for HBV infection. It also sheds light on how the body protects against spread of an ongoing infection without destroying vital organs."

Scientists have thought that cell-killing T cells bring hepatitis B virus infections to an end by destroying infected liver cells. The current study, however, points to a noncytolytic process that targets the virus' ability to reproduce and leaves the liver relatively unscathed.

Luca G. Guidotti, D.V.M., Ph.D., and Francis V. Chisari, M.D., of the Scripps Research Institute in La Jolla, Calif., led the study, in collaboration with Robert H. Purcell, M.D., chief of NIAID's hepatitis viruses section, and other scientists. The researchers infected two healthy chimpanzees with HBV, then performed weekly blood and liver tests on the animals throughout the course of the infection.

The chimp HBV infections ran their course and the animals recovered without further complications. Most HBV infections in adult humans are similarly uncomplicated. However, between 5 and 10 percent of the estimated 320,000 new HBV infections in the United States each year become persistent, chronic infections. Annually, chronic HBV infection kills as many as 6,000 people in this country.

The researchers found the amount of hepatitis B virus DNA in the chimps' blood and livers peaked eight weeks after infection. The HBV DNA levels then rapidly decreased - by week 12 more than 90 percent of the HBV DNA
'"/>

Contact: John Bowersox
jbowersox@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
30-Apr-1999


Page: 1 2

Related biology news :

1. Immune systems attack dogs kept on genetic leash
2. Immune system drug may increase availability of liver transplants
3. Immune cells may help deliver cancer vaccines for children
4. Immune response depends on key molecule: Research
5. Applied Biosystems and Immune Tolerance Network announce immunology research agreement
6. Immune system component found common to both humans and worms
7. Immune cells SLAP internal signals together
8. Immune co-stimulation and the Kaposis virus
9. Immune system helps prevent tumors after all
10. Even the Immune System works with Pincers
11. Immune system chemical may predict worsening of coronary heart disease in women

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune Response Hepatitis Spares Liver Cells

(Date:8/29/2014)... Researchers at UC Davis have made some surprising ... infection. Studying simian immunodeficiency virus (SIV), the team ... Paneth cells are early responders to viral invasion ... producing a cytokine called interleukin-1 beta (IL-1β). ... IL-1β causes breakdown of the gut epithelium that ...
(Date:8/29/2014)... at the Barshop Institute for Longevity and Aging Studies, ... Health Science Center at San Antonio, have found another ... rodent, the naked mole rat. , They reported ... rats protects and alters the activity of the proteasome, ... The factor also protects proteasome function in human, mouse ...
(Date:8/29/2014)... has been known about what genetic changes transform wild ... one of whom is a University of Montana assistant ... controlling the development of the brain and the nervous ... was published Aug. 28 in Science and ... at http://www.sciencemag.org/ ., The domestication of animals and ...
Breaking Biology News(10 mins):The early cost of HIV 2Factor in naked mole rat's cells enhances protein integrity 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3
(Date:8/29/2014)... Inc. (NYSE MKT: PFNX), a clinical-stage biotechnology company ... to manufacture proteins including biosimilar therapeutics, today provided ... the second quarter ended June 30, 2014. ... public offering, we have the capital to continue ... our proprietary protein expression platform," stated Bertrand C. ...
(Date:8/29/2014)... electrons, but one of the most promising technologies for ... on light (photons) instead of electrons. First, it is ... single photons and control their direction. Researchers around the ... this control, but now scientists at the Niels Bohr ... photons emitted one at a time and in a ...
(Date:8/29/2014)... 29, 2014 The global companion ... in 2019. It is expected to grow at ... and was valued at $1.8 billion in 2013, ... Market Research. , For more information regarding analysis ... , The research report, titled “Companion Diagnostics Market ...
(Date:8/29/2014)... August 29, 2014 According to a new ... the global orthobiologics market was valued at USD 3,754.6 million ... USD 5,519.9million in 2019at a CAGR of 5.9% from 2013 ... years and above is afflicted by bone and joint disorders, ... year 2020. This has and will continue to increase the ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Breakthrough in light sources for new quantum technology 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
Cached News: