HOME >> BIOLOGY >> NEWS
Immune Response To Hepatitis B Spares Liver Cells

A new study suggests that, contrary to current belief, the immune system eliminates most hepatitis B virus (HBV) without resorting to large-scale destruction of infected liver cells. A report of the study, conducted by National Institute of Allergy and Infectious Diseases (NIAID) grantees and scientists, appears in the April 30, 1999, issue of Science.

"This is an intriguing finding," notes NIAID Director Anthony S. Fauci, M.D. "By advancing our understanding of how HBV is cleared from the liver, it could lead to better treatments for HBV infection. It also sheds light on how the body protects against spread of an ongoing infection without destroying vital organs."

Scientists have thought that cell-killing T cells bring hepatitis B virus infections to an end by destroying infected liver cells. The current study, however, points to a noncytolytic process that targets the virus' ability to reproduce and leaves the liver relatively unscathed.

Luca G. Guidotti, D.V.M., Ph.D., and Francis V. Chisari, M.D., of the Scripps Research Institute in La Jolla, Calif., led the study, in collaboration with Robert H. Purcell, M.D., chief of NIAID's hepatitis viruses section, and other scientists. The researchers infected two healthy chimpanzees with HBV, then performed weekly blood and liver tests on the animals throughout the course of the infection.

The chimp HBV infections ran their course and the animals recovered without further complications. Most HBV infections in adult humans are similarly uncomplicated. However, between 5 and 10 percent of the estimated 320,000 new HBV infections in the United States each year become persistent, chronic infections. Annually, chronic HBV infection kills as many as 6,000 people in this country.

The researchers found the amount of hepatitis B virus DNA in the chimps' blood and livers peaked eight weeks after infection. The HBV DNA levels then rapidly decreased - by week 12 more than 90 percent of the HBV DNA
'"/>

Contact: John Bowersox
jbowersox@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
30-Apr-1999


Page: 1 2

Related biology news :

1. Immune systems attack dogs kept on genetic leash
2. Immune system drug may increase availability of liver transplants
3. Immune cells may help deliver cancer vaccines for children
4. Immune response depends on key molecule: Research
5. Applied Biosystems and Immune Tolerance Network announce immunology research agreement
6. Immune system component found common to both humans and worms
7. Immune cells SLAP internal signals together
8. Immune co-stimulation and the Kaposis virus
9. Immune system helps prevent tumors after all
10. Even the Immune System works with Pincers
11. Immune system chemical may predict worsening of coronary heart disease in women

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune Response Hepatitis Spares Liver Cells

(Date:9/2/2015)... FELTON, California , September 2, 2015 /PRNewswire/ ... with the security purpose implied in a system ... hand geometry, voice, signature, iris, vein, DNA and ... crimes has forced to develop such system which ... by username, password, PIN, Patterns and tokens are ...
(Date:8/31/2015)... , Aug. 31, 2015 Research and Markets ... "Saudi Arabia Biomedical Sensors Market - Growth, Trends ... The Saudi Arabia Biomedical Sensors market is ... of 3.64% over the period 2014-2020 The ... to the genetic formulation of each individual. These sensors ...
(Date:8/25/2015)... CITY and BELLEVUE, Wash. ... leader in advanced robotic systems, announced today it will ... unmanned ground vehicle (UGV), at the National Tactical Officers ... The Guardian S is the first-ever ... culmination of years of research and in-field trials and ...
Breaking Biology News(10 mins):Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 2Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 4Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3
(Date:9/2/2015)... 2015  Neurotech Pharmaceuticals, Inc., announced today the ... Phase 2 clinical trial of NT-503 Encapsulated Cell ... subfoveal choroidal neovascularization secondary to age related macular ... endothelial growth factor (VEGF) receptor protein continuously produced ... landmark proof-of-concept study will evaluate NT-503 ECT as ...
(Date:9/2/2015)... , Sept. 2, 2015 Aytu BioScience, Inc. ... treatments for urological and related conditions, announced today that ... private placement convertible note financing, raising a total of ... totaling $3.175 million. Josh Disbrow ... this private placement are intended to be used to ...
(Date:9/2/2015)... TEL-AVIV, Israel , September 2, 2015 /PRNewswire/ ... BLGTY, TASE: BOLT) ("BioLight" or the "Company"), a ... innovations in ophthalmology and cancer diagnostics, announced today ... treatment of glaucoma will be delivered at the ... of the European Society of Cataract & Refractive ...
(Date:9/2/2015)... , September 2, 2015 ... des Wettbewerbs BeHEARD von 2015 bekanntgeben zu können. ... Rare Genomics Institute. Biovista unterstützt mit ... für die Behandlung anderer Krankheiten als denen, für ... Laffoon und sein Team bei der Wylder ...
Breaking Biology Technology:Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 2Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 3Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 4Aytu BioScience Completes $5.175 Million Private Placement 2Aytu BioScience Completes $5.175 Million Private Placement 3Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2
Cached News: