HOME >> BIOLOGY >> NEWS
Immune cells SLAP internal signals together

SLAP protein signal found to connect components of immune cell activation: finding has implications for cancer treatments and autoimmune diseases

(Philadelphia, PA) In a way, the immune system works like throwing a fistful of darts while blindfolded if you throw enough some may actually hit the dartboard. Since the immune system does not know ahead of time what a particular threat looks like, it generates T cells, a type of white blood cell, with uniquely random T cell receptors (TCRs). Once the TCR gets activated by latching onto a target it begins a cascade of signals and counter-signals that work in order to prepare the T cell for action. In this weeks issue of the journal, Science, researchers from the University of Pennsylvania School of Medicine report their findings on the role of one signal, the SLAP-130 protein, in bridging together chemical pathways in order to activate T cells.

"Once the immune system finds the TCR that sticks to a specific target, it generates more copies of that T cell and readies them to seek out the target a process that is regulated by an intricate network of chemical reactions," said Gary A. Koretzky, PhD, professor in the Penn Department of Pathology and Laboratory Medicine, and researcher for the Abramson Family Cancer Research Institute at the Penn Cancer Center. "Part of our goal is to figure out which signal does what in this activation process."

According to Koretzky, the SLAP-130 protein is an integral part of generating an immune response. Using a mouse model, Koretzky and his colleages were able to place SLAP-130 in the chain of reactions that couple TCR activation with the activation of integrins, large molecules on the outside of T cells that help them stick to their targets. Without SLAP-130 to link the two processes together, T cells are not able to get the integrins to work properly.

"By identifying how T cells are activated, we hope to gain a better understanding of how T ce
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
21-Sep-2001


Page: 1 2

Related biology news :

1. Immune systems attack dogs kept on genetic leash
2. Immune system drug may increase availability of liver transplants
3. Immune cells may help deliver cancer vaccines for children
4. Immune response depends on key molecule: Research
5. Applied Biosystems and Immune Tolerance Network announce immunology research agreement
6. Immune system component found common to both humans and worms
7. Immune co-stimulation and the Kaposis virus
8. Immune system helps prevent tumors after all
9. Even the Immune System works with Pincers
10. Immune system chemical may predict worsening of coronary heart disease in women
11. UWs new Cell Systems Initiative welcomes Immunex collaboration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
(Date:5/23/2017)... the first robotic gym for the rehabilitation and functional motor sense evaluation ... Genoa, Italy . The first 30 robots will be available from ... . The technology was developed and patented at the IIT laboratories ... Technology thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time ... US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. ... US2020. , US2020’s mission is to change the trajectory of STEM education in ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced the ... NIH to develop RealSeq®-SC (Single Cell), expected to be ... small RNAs (including microRNAs) from single cells using NGS ... the need to accelerate development of approaches to analyze ... "New techniques for measuring levels of mRNAs ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings ... mechanism by which its ProCell stem cell therapy ... limb ischemia.  The Company, demonstrated that treatment with ... of limbs saved as compared to standard bone ... molecule HGF resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology:
Cached News: