HOME >> BIOLOGY >> NEWS
Immune molecule found to kill indirectly by closing receptor to live-saving help

Instead of killing damaged cells directly as once believed, an immune molecule works behind the scenes, shutting down receptors within neurons that normally welcome a separate life-saving protein with open arms, a team of scientists says.

The discovery, reported in the Aug. 17 issue of the Proceedings of the National Academy of Sciences, sheds new insight on the cross-talk of two proteins-- insulin-like growth factor, a life-promoting molecule, and an inflammatory cytokine known as tumor necrosis factor alpha (TNF)-- within damaged cells. The findings could become important in the treatment of brain injuries and of Alzheimer's, stroke, multiple sclerosis and AIDS dementia, all of which involve neurodegeneration.

The brains of animals with these injuries and diseases have been injected with large amounts of IGF-I, a pharmaceutical replica of natural growth hormone produced by the liver, to encourage the healing of damaged cells. But, for unexplained reasons, results have not been 100 percent positive.

"Our findings are about life and death and survival of damaged neurons," said Keith W. Kelley, an animal scientist at the University of Illinois and president of the PsychoNeuroImmunology Research Society ( http://www.pnirs.org ).

"Previously, it was believed that IGF and TNF acted completely separately, with IGF inducing life and survival, and TNF simply killing cells directly. Instead TNF is more effective by killing neurons indirectly by scrambling the signal so IGF cannot bind to target cells and produce a survival enzyme", said Homer D. Venters, a student in the M.D.-Ph.D. medical scholars program in the U. of I. College of Medicine at Urbana-Champaign.

The team's findings are based on in vitro experiments with neurons cultured from normal mice. In mammals, IGF induces muscle protein synthesis, enhancing growth and weight gain, except in the pr
'"/>

Contact: Jim Barlow, Life Sciences Editor
b-james3@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
17-Aug-1999


Page: 1 2

Related biology news :

1. Immune systems attack dogs kept on genetic leash
2. Immune system drug may increase availability of liver transplants
3. Immune cells may help deliver cancer vaccines for children
4. Immune response depends on key molecule: Research
5. Applied Biosystems and Immune Tolerance Network announce immunology research agreement
6. Immune system component found common to both humans and worms
7. Immune cells SLAP internal signals together
8. Immune co-stimulation and the Kaposis virus
9. Immune system helps prevent tumors after all
10. Even the Immune System works with Pincers
11. Immune system chemical may predict worsening of coronary heart disease in women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... August 06, 2020 , ... Alucio™, a ... announce that Eric Chen and Jessica Wong have joined the company’s leadership team ... respectively. , Eric Chen heads development efforts for Alucio’s flagship product, Beacon, an ...
(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is ... medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. ... chain for more than 10 years. Early in the COVID-19 crisis, we identified ...
(Date:7/22/2020)... SANTA BARBARA, Calif. (PRWEB) , ... July 21, ... ... consulting firm driving digital transformation and innovation in technology and compliance, announces a ... and medical device companies must ensure every layer of their technology stack complies ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society announced today ... Clinical Trial Research Network (FSHD CTRN), with consideration of follow-on funding ... of academic research centers in the United States and Europe with expertise in ...
(Date:8/3/2020)... ... 2020 , ... ERT, the global leader in ... named one of the 100 most inspiring individuals in the life-sciences industry by ... based on how they have inspired their colleagues and affected positive changes in ...
(Date:7/31/2020)... BEDFORD, Mass. (PRWEB) , ... July 29, 2020 ... ... of highly reliable, solid-state radar transmitter systems that can be configured to drive ... a single controller that can drive one or two switches in a push-pull ...
(Date:7/31/2020)... ... July 29, 2020 , ... The ... centers in 16 countries, has reached its 20th anniversary of worldwide use. Introduced ... use at top universities including University of Pennsylvania, University of Michigan, University of ...
Breaking Biology Technology:
Cached News: