HOME >> BIOLOGY >> NEWS
Immune system component found common to both humans and worms

When someone gets a bacterial infection, the human body mounts a complex set of reactions aimed at destroying the invader. The role of what is called the innate immune system -- one of the most basic aspects of the overall immune response -- is to sound the alarm and jump start the body's response to pathogens. Researchers have known that key components of innate immunity are conserved across a variety of animals, and now scientists at Massachusetts General Hospital (MGH) have shown that these same elements are used by the lowly worm as well. The findings, published in the July 26 issue of Science, suggest that scientists will now be better able to tease out the details of innate immunity across a wide range of species.

"Innate immunity plays a central role in the initial encounter with foreign pathogens and is thus critical to the host's defense against infection," says co-lead author Dennis Kim, MD, PhD, of the MGH Department of Molecular Biology. "But derangement of the innate immune system is implicated in the pathogenesis of overwhelming infections, as well as in chronic inflammatory diseases. We anticipate that learning about fundamental aspects of the innate immune system may lead to therapies for these conditions." Because innate immunity is conserved among most animals, scientists have been studying it in the laboratory using insect models. This new report gives researchers another tool.

"The C. elegans nematode worm is more primitive than an insect, and it's an excellent model organism that has provided scientists with insights into development and other basic biological processes. We hope that our study provides the basis for now using the worm to study immune function," says principal investigator Frederick Ausubel, PhD, of the MGH Department of Molecular Biology.

Ausubel's team has previously noted that human pathogens, such as certain bacteria, can also kill C. elegans. So Ausubel, Kim and co-lead author Rhonda Feinbaum
'"/>

Contact: Susan McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
25-Jul-2002


Page: 1 2

Related biology news :

1. Immune systems attack dogs kept on genetic leash
2. Immune system drug may increase availability of liver transplants
3. Immune cells may help deliver cancer vaccines for children
4. Immune response depends on key molecule: Research
5. Applied Biosystems and Immune Tolerance Network announce immunology research agreement
6. Immune cells SLAP internal signals together
7. Immune co-stimulation and the Kaposis virus
8. Immune system helps prevent tumors after all
9. Even the Immune System works with Pincers
10. Immune system chemical may predict worsening of coronary heart disease in women
11. UWs new Cell Systems Initiative welcomes Immunex collaboration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 20, 2020 , ... ... Hassan Movahhed , a Clinical Operations executive with expertise in clinical trial planning ... the firm as an Expert Consultant. Throughout his career, Mr. Movahhed has helped ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... pleased to announce that Eric Chen and Jessica Wong have joined the company’s ... & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s flagship product, ...
(Date:8/3/2020)... ... 03, 2020 , ... Accumen Inc. is helping healthcare get ... Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , “Accumen has ... than 10 years. Early in the COVID-19 crisis, we identified supply chain gaps ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... industry, today announced the release of its signature product called Beacon - ... (MSLs) and other field medical professionals. , Beacon helps MSLs streamline ...
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
(Date:7/10/2020)... ... 2020 , ... In most research using the zebrafish model, ... in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past ... the zebrafish model to investigate the causes of leukaemia and its relationship with ...
(Date:7/1/2020)... ... 29, 2020 , ... MedShift , a leading medical ... many obstacles created as a result of COVID-19. As a provider at the ... practices and medical manufacturers by expanding access to device offerings, technology services, and ...
Breaking Biology Technology:
Cached News: