Imperial researchers show novel flu treatment eliminates symptoms in mice

Imperial College London researchers report today in the Journal of Experimental Medicine that they have developed a novel strategy for effectively treating the symptoms of the most deadly type of flu.

Working with influenza A virus, they show in mice that their novel treatment eliminates symptoms by reducing the response of active T white blood cells by a third.

Flu A is the type of influenza responsible for pandemics such as the 1919 outbreak of 'Spanish flu', which globally killed more than 20 million people.

Unlike current attempts to prevent or treat flu, which rely on either yearly vaccinations that try to predict how the virus might mutate, or anti viral drugs that must be administered as soon as there is contact with the virus, this new treatment can be given after symptoms present.

Dr Tracy Hussell of Imperial's Centre for Molecular Microbiology and Infection and senior author of the paper, says:

"Three times in recent history the flu virus has evolved from a disease characterised by coughs and sneezes to a world killer. The recent SARS epidemic highlights how quickly a deadly virus can spread in modern society and we are long overdue for the next flu pandemic. The sobering reality is that influenza is one of the grand masters at evading human immune response.

"During flu infection the immune system has an 'all hands on deck' attitude to the viral assault. But it's this that causes most of the damage. The exaggerated immune response produces inflammatory molecules that lead to what's known as a 'cytokine storm'. Essentially too many cells clog up the airways and prevent efficient transfer of oxygen into the bloodstream.

"By selectively reducing this cellular load we've shown it's possible to eliminate clinical symptoms whilst effectively tackling and clearing the infection."

The body has two major classes of white blood cells, T and B lymphocytes. While B cells produce tailor-made antibodies

Contact: Judith Moore
Imperial College London

Page: 1 2 3

Related biology news :

1. Pioneering flu researcher wins major Imperial scientific award
2. Press invitation: The Future of Medical Technology: 2001-2010 - Anglo-Japanese Healthcare Conference at Imperial College, London
3. Press invitation: The science of stem cells - December symposium at Imperial College
4. Belgian researchers explore revolutionary approach to angiogenesis
5. Award winning researchers reveal potential new role for Glivec
6. $7.5 Million grant to Yale researchers for role of viruses in cancer
7. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
8. Joslin researchers clarify mechanisms for beta-cell formation
9. Virginia Tech researchers to release findings on Smith River Project
10. Molecular motor myosin VI moves hand over hand, researchers say
11. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy

Post Your Comments:

(Date:8/7/2020)... ... August 06, 2020 , ... Alucio™, ... to announce that Eric Chen and Jessica Wong have joined the company’s leadership ... Strategy, respectively. , Eric Chen heads development efforts for Alucio’s flagship product, Beacon, ...
(Date:7/31/2020)... , ... July 30, 2020 , ... ... digital therapeutics product portfolio with a near term focus on Type 2 diabetes ... pharma commercialization experience across multiple therapeutic areas and classes. As Chief Commercial Officer, ...
(Date:7/10/2020)... ... , ... Today CJ BIO announced the first in a series of Food ... phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range ... 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® ... in 16 countries, has reached its 20th anniversary of worldwide use. Introduced in ... at top universities including University of Pennsylvania, University of Michigan, University of Maryland, ...
(Date:7/18/2020)... , ... July 16, 2020 , ... “We are thrilled ... Wave Bioactives. “It’s the only technology of its kind on the market and we ... onions with the protective capacity of traditional cultured ingredients, creating a natural way to ...
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
(Date:7/7/2020)... ... , ... Bio-IT World has announced the winners of the ... of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were honored. ... examples of how technology innovations and strategic initiatives can be powerful forces for ...
Breaking Biology Technology:
Cached News: