HOME >> BIOLOGY >> NEWS
Important Genetic Marker For Alzheimer's Disease Questioned

A team of researchers from the University of Toronto, Boston University School of Medicine, Duke University and Vanderbilt University, has determined that recent findings suggesting a gene on chromosome 12 was a strong genetic risk factor for Alzheimer's disease cannot be replicated. The results of the investigation will appear in the May issue of Nature Genetics.

It had been reported that the A2M-2 variant of the alpha-2-macroglobulin gene on chromosome 12 was a strong risk factor for Alzheimer's. Investigators had suggested that the increase in risk related to A2M-2 was equal to (or possibly greater than) the strongest known existing risk factor, the e4 variant of apolipoprotein E.

However, the multinational consortium investigating the suspected association could not replicate those results after evaluating A2M in more than 100 Alzheimer's families. Families consisted of multiple members afflicted with the disease. The investigation also included nearly 400 cases of sporadic Alzheimer's disease, and 320 age-matched cognitively normal controls. There was no evidence for an association between the A2M-2 and increased Alzheimer's risk in any patient sample. Researchers determined that the A2M-2 was likely to be a natural genetic variant which does not cause Alzheimer's disease.

"Alzheimer's is a complex disease with multiple genetic risk factors that are difficult to sort out, so it is doubly important that suggested associations can be replicated," said Margaret Pericak-Vance, PhD, professor of medicine and director of the Center for Human Genetics, Duke University Medical Center. "Our results with the e4 variant of apolipoprotein E have been replicated by investigators dozens of times worldwide, but the search continues for the Alzheimer's gene on chromosome 12," she added.

Despite negating the suspected association, the researchers maintain that there is strong and reproducible evidence for another genetic defect, which does cause Alzheimer's,
'"/>

Contact: Steven de Sousa
steven.desousa@utoronto.ca
416-978-5949
University of Toronto
30-Apr-1999


Page: 1 2

Related biology news :

1. Important step taken toward the identification of schizophrenia genes
2. Important pathogens and cures belong to little-known group of fungi
3. Scientists Discover Important Molecular Link That Allows Cells To Form Blood Vessels
4. New Gene May Play Important Role In Regulating HDL, The Good Cholesterol
5. Structure Of Fat-Depleting Protein Reveals Important Functional Clues
6. Important New Fossil Animal Discovered By Wits Scientists
7. UI Study Reveals Important Information About Molecular Defect In Limb Girdle Muscular Dystrophy
8. Researchers Find Fas Ligand Is Important In Blinding Disease
9. Oregon Scientists Discover A Second Blood-Brain Barrier; Important Finding For Patients With Brain Cancers And Neurological Disorders
10. One Way Traffic: Max Planck Scientists Idendified Genes Involved In Transporting An Important Plant Growth Factor
11. UCSF Team Identifies Two Key Molecules In Asthma; Important Finding For New Therapies That Treat Disease At Cell Level

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... Personal eye wash is a basic first aid supply for any work ... which eye do you rinse first if a dangerous substance enters both eyes? It’s one ... with its unique dual eye piece. , “Whether its dirt and debris, or an ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... it will be hosting a Webinar titled, “Pathology is going digital. Is your ... on digital pathology adoption best practices and how Proscia improves lab economics and ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
Breaking Biology Technology:
Cached News: