"While undernutrition's role in exacerbating diarrheal disease and respiratory infections is well known, scientific evidence has been mixed regarding its role in malaria infection," explained lead author Laura E. Caulfield, PhD, an associate professor with the Bloomberg School of Public Health's Center for Human Nutrition. "Despite the fact that people have thought that undernutrition prevents malaria, the bulk of evidence suggests that undernutrition contributes significantly to the malaria burden."
Nearly 550,000 annual malaria deaths are attributable to underweight in children less than 5 years of age, according to global burden of disease data published earlier this year. The investigators looked at malaria morbidity and mortality risk due to underweight and specific micronutrient deficiencies in countries including The Gambia, Vanuatu, Ghana, Guinea-Bissau and Senegal. While underweight children had only a slightly increased risk of a clinical malaria attack, the data on mortality risk in underweight children were dramatic. Mildly malnourished children were 2 times more like to die from malaria than children who are not undernourished, while moderately malnourished children were 4 times more likely to die. Severely malnourished children were 9 times more likely to die. While the risk of malaria mortality increases with the severity of undernutrition, most child deaths occur in only mildly to moderately undernourished children, b
Contact: Kenna L. Lowe
Johns Hopkins University Bloomberg School of Public Health