HOME >> BIOLOGY >> NEWS
Improvement in some patients who underwent neuronal transplantation following stroke, according to study by University of Pittsburgh researchers

PITTSBURGH, April 11 -- Douglas Kondziolka, M.D., professor of neurological surgery and radiation oncology at the University of Pittsburgh department of neurological surgery, reported today that some patients who underwent neuronal transplantation following stroke showed improvement in motor function.

His study, presented at the annual meeting of the American Association of Neurological Surgeons in San Francisco, reported on the six-month neurologic outcome and 12-to-18 month safety data of patients in the first research study of a treatment aimed at reversing neurological deficits from stroke.

Dr. Kondziolka's study involved 12 patients in a phase I trial that evaluated the safety and feasibility of implanting human neuronal cells for treatment of chronic stroke in the basal ganglia region of the brain.

The nine men and three women in the study varied in age from 44 to 75 years. In eight patients, the stroke involved only the basal ganglia region of the brain and in four patients, both the basal ganglia and regional cortex were involved. All patients had stable neurologic deficits at least two months prior to implantation. The first four patients were treated with two million neurons implanted at three sites along a single needle pass within the basal ganglia. The remaining eight patients were randomized to receive either two million neurons along one needle pass or a total of six million neurons implanted along three trajectories.

Assessment of safety and feasibility was performed using the NIH Stroke Scale (NIHSS), European Stroke Scale (ESS), Short Form 36 (SF36) and Barthel Index (BI).

Following implantation, subjective improvement, which included increased strength, sensation and coordination, was reported in eight patients.

Objectively, six patients had an increase in ESS score ranging from three to 10 points, with four of these patients improving by eight or more points. Thre
'"/>

Contact: Frank Raczkiewicz
raczkiewiczfa@msx.upmc.edu
412-624-2607
University of Pittsburgh Medical Center
10-Apr-2000


Page: 1 2 3

Related biology news :

1. Food allergy reactions in schools: Improvements needed to reduce and respond
2. Improvement in controlling agricultural runoff still needed to prevent ecological disasters
3. Groundwater Remediation: New Tool Offers Improvement
4. School Breakfast Participation Leads To Academic, Psychosocial Improvements
5. Trial shows which brain cancer patients benefit from temozolomide
6. Study of flu patients reveals virus outsmarting key drug
7. Decreasing toxins in brains of Alzheimers patients keep cognitive deficits at bay
8. Activated signaling pathway may predict lung cancer patients response to gefitinib
9. Targeted therapy for lung cancer patients shows promise in extending lives
10. Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
11. Study finds that only half of a commonly used cancer drug is activated in cancer patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/6/2019)... (PRWEB) , ... November 06, 2019 , ... ... that Donald Stanski, MD, a senior pharmaceutical industry executive with expertise in clinical ... simulation for drug and disease strategic data analytics, has joined the firm as ...
(Date:11/5/2019)... ... November 05, 2019 , ... Dr. Lauren Kopp ... dentistry to Seattle, WA, including porcelain veneers , smile makeovers, dental implants, ... University of Washington, Dr. Kopp is passionate about serving her Seattle community with ...
(Date:10/30/2019)... ... October 30, 2019 , ... The 2019 ... Center in which participants will learn about precision agriculture tools used to enhance ... technologies. , Participants will have the opportunity to visit Virginia Tech’s agricultural ...
Breaking Biology News(10 mins):
(Date:10/29/2019)... ... , ... Modality Solutions, a biopharmaceutical cold chain ... workshop at the Biomanufacturing World Summit (BMWS19) Conference, November 11-12, 2019, at the ... World Summit brings together pharmaceutical executives, cutting-edge technology providers, and media partners ...
(Date:10/22/2019)... ANGELES (PRWEB) , ... October 22, 2019 , ... ... provider, today announced integration of the Alertus Mass Notification System into its digital ... infrastructure to the Enplug platform, making it possible for users to leverage their ...
(Date:10/10/2019)... BETHESDA, Md. (PRWEB) , ... October 09, 2019 ... ... announced Amy Abernethy, MD, PhD, Principal Deputy Commissioner, FDA, as a newly-confirmed ... place 27–30 October 2019 in Las Vegas, Nevada USA. , Dr. Abernethy, a ...
(Date:10/8/2019)... Fla. (PRWEB) , ... October 07, 2019 , ... ... development of low level laser therapy technology (“3LT®”), today announces that the U.S. ... market its EVRL low level laser for the temporary relief of chronic neck ...
Breaking Biology Technology:
Cached News: