HOME >> BIOLOGY >> NEWS
In potentially important discovery, scientists find two forms of genetic material chromatin

CHAPEL HILL -- Biologists have discovered what appear to be fundamental differences in the physical properties of the genetic material known as chromatin. Chromatin packages DNA into cells, and the scientists found the differences between chromatin that packages genes and the chromatin that packages DNA with regulatory or unknown functions.

The variation represents a previously unrecognized level of genomic organization and complexity, the scientists report, one that may exist in all cells with nuclei.

Made in yeast, the discovery offers broad potential uses, said Dr. Jason D. Lieb, a University of North Carolina at Chapel Hill biologist and a report author.

"For example, in pathology laboratories, differences in chromatin shape and structure in mammalian cells are routinely determined by staining tissues and observing them under a microscope," said Lieb, also a Carolina Center for the Genome Sciences researcher. "This is an important assay used to identify specific cell types and malignancies. It is possible that a detailed genomic view of these variations, provided by the method we describe in our paper, could be used to diagnose and sub-type cancer and other diseases."

It also could be an important tool for assigning functions to subsections of the genome, particularly for finding active genes, which remains a difficult problem, he said.

The report will appear online this week and in the May 27 issue of the Proceedings of the National Academy of Sciences. Other authors, all at Stanford University, are Drs. Peter L. Nagy and Michael L. Cleary of pathology and Dr. Patrick O. Brown of biochemistry.

"If the DNA from a single human chromosome were stretched and measured end-to-end, it would extend to over half an inch in length," Lieb said. "Our cells are much, much smaller than that, of course, and in order to fit inside the cell's nucleus, which is even smaller, DNA must be compacted about 1,000-fold relative to i
'"/>

Contact: David Williamson
919-962-8596
University of North Carolina at Chapel Hill
13-May-2003


Page: 1 2 3

Related biology news :

1. Computer method identifies potentially active enzymes
2. California pistachio industry threatened by potentially devastating disease
3. Researchers find a new way to potentially thwart anthrax
4. A derivative of the green tea leaf may help with Metabolic Syndrome X, a potentially deadly disorder
5. Ultrasound shown to be potentially safe, effective way to kill bacteria
6. First potentially clinically useful independent marker for lung cancer identified
7. Researchers suggests a potentially damaging effect of extremely low frequency electromagnetic fields
8. URI biological oceanographers study potentially toxic microalgae on the northeast coast
9. Study: Showering boosts concentrations of potentially hazardous trihalomethanes
10. Black raspberries a potentially powerful agent in fight against colon cancer
11. Cancer-detecting microchip - a micromachined cantilever - is sensitive assay for prostate cancer and potentially other diseases, researchers report

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... HOUSTON (PRWEB) , ... October 15, 2018 , ... ... integrated cold chain operations solutions for highly regulated industries, is a silver sponsor ... in San Diego, California. , The Biomanufacturing World Summit brings together ...
(Date:10/13/2018)... ... October 12, 2018 , ... ... will host a booth at premier packaging event PACK EXPO International in Chicago ... Machinery Manufacturers Institute (PMMI), of which HOLLOWAY AMERICA is a member. , At ...
(Date:10/11/2018)... YORK (PRWEB) , ... October 10, 2018 , ... ... technology is enabling newly diagnosed breast cancer patients to learn about their treatment ... outcomes for women with triple negative breast cancer (TNBC), and was developed through ...
Breaking Biology News(10 mins):
(Date:10/5/2018)... (PRWEB) , ... October 04, 2018 , ... ... diagnostics with genomics, along with Duke University, announced today at IDWeek™ 2018 the ... test that detects pathogen DNA in plasma, accurately identified causative pathogens in patients ...
(Date:10/2/2018)... ... October 02, 2018 , ... Genedata, ... a new out-of-the-box integration of the Genedata Bioprocess ® platform with ... equipment supplier. This enables the automatic import of raw instrument data into ...
(Date:9/29/2018)... GARDEN GROVE, Calif. (PRWEB) , ... September 29, ... ... Voxx.Gateway, an analytics product enabling mid-level and early-stage companies to access the power ... working to make our solutions available to a broader market that didn’t necessarily ...
(Date:9/27/2018)... ... September 26, 2018 , ... ... ahead of their primary care physicians, according to a new Zeldis Research and ... and doctors were asked about consumer adoption of fitness and health wearables, remote ...
Breaking Biology Technology:
Cached News: