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In vitro fertilization may be linked to bladder defects

od, researchers estimate the incidence of these birth defects are up to 7.3 times more common in the IVF population.

The most common defect of the exstrophy-epispadias complex is bladder exstrophy, a condition in which the bladder is exposed, inside out, and protrudes through the abdominal wall. In addition, the skin on the lower abdomen does not form properly, the pelvic bones are widely spaced, and there may be genital abnormalities.

"With reconstructive surgery, we can close abdominal wall defects, reform the pelvic bones, create normal appearing external genitalia, and help the child gain urinary continence. Following surgery, most children go on to live a normal life with normal bladder and reproductive function," said Gearhart.

Exstrophy-epispadias is four to six times more likely in boys than girls. Researchers believe these birth defects are caused by failed development of the urogenital system during the first trimester of pregnancy.


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Contact: Jessica Collins
jcolli31@jhmi.edu
410-516-4570
Johns Hopkins Medical Institutions
18-Mar-2003


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