Vaccines are designed to protect people by boosting the immune system to kill parasites but, unless a malaria vaccine leads to the death of every single parasite, the ones that survive are likely to be the nastiest. The new research by Dr Margaret Mackinnon and Professor Andrew Read, of the University of Edinburgh's Institute of Cell, Animal & Population Biology, sought to investigate how vaccination can, in fact, lead to the evolution of more virulent strains of the disease.
Initially, the Edinburgh researchers directly injected two groups of mice with infectious parasites - "immunised" mice, which had been exposed to Plasmodium and then treated with the anti-malarial drug, mefloquine, and "nave" mice, which had not. They then transferred parasites via a syringe from host to host 20 times. The parasites thus evolved in the immune or non-immune environments. The parasites that evolved in the immunised mice were more virulent than parasites evolved in the naive mice.
The researchers then tested whether this increased virulence would be retained if parasites were transmitted by a mosquito, rather than through a syringe. Infection was not as severe after transmission through mosquitoes - an intriguing finding in itself - but the effect was still there. In other words, immunity accelerates the evolution of virulence in malaria, even after mosquito transmission, making them more dangerous to their non-immunised hosts.
Dr. Mackinnon said: "How does immune selection create more virulent path
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Contact: Catriona Maccallum
cmaccallum@plos.org
44-122-349-4488
Public Library of Science
22-Jun-2004