HOME >> BIOLOGY >> NEWS
Increased bone mass in a calcitonin knockout mouse full of surprises

Find below one highlighted articles and the full Table of Contents for the December 16 issue.

****************************************************

Increased bone mass in a calcitonin knockout mouse full of surprises

Bone is in a constant state of remodeling, during which osteoclasts remove old bone (resorption) and osteoblasts form new bone (formation). Calcitonin is a hormone produced by the thyroid gland and inhibits bone resorption. Following menopause, the rate of bone loss is accelerated, however women with post-menopausal osteoporosis that are treated with calcitonin (by injection or nasal spray) demonstrate increased bone mass and strength, in addition to a decrease in the rate of bone fractures. Following alternative processing, the gene encoding calcitonin (CT/CGRP) also encodes a second peptide: calcitonin gene-related peptide-a (CGRPa), however the role of this peptide in bone metabolism has not been clearly defined.

To better understand the role of calcitonin and CGRP-a in bone metabolism Robert Gagel and colleagues at the University of Texas M.D. Anderson Cancer Center, USA, created mice in which the CT/CGRP gene had been deleted. Given that both calcitonin and CGRP have been shown to inhibit bone resorption and CGRP is known to stimulate bone formation, the authors predicted that there would be either no effect of this deletion on bone mass, or there could be some bone loss.

In the December 16 issue of the Journal of Clinical Investigation, the authors report their surprising finding that CT/CGRP-deficient mice have greater bone mass, increased bone formation, and were able to maintain bone mass during estrogen deficiency by increasing bone formation. These findings suggest an important and novel function for the products of the CT/CGRP gene, that was previously unrecognized. They also suggest that the development of an antagonist to the CT/CGRP gene product(s)
'"/>

Contact: Brooke Grindlinger, Ph.D.
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-Dec-2002


Page: 1 2

Related biology news :

1. Increased atmospheric carbon dioxide promotes algal growth
2. Increased temperature may prevent winter flounder from rebounding in east coast estuaries
3. Get your blood moving: Increased blood flow could lead to healthier blood vessels
4. Increased fiber curbs appetite in women
5. Increased CO2 levels are mixed blessing for agriculture
6. Increased awareness of stroke symptoms could dramatically reduce stroke disability
7. Increased use of chemicals in agriculture worldwide seen as major environmental threat
8. Increased consumption of soy protein may help lower cholesterol
9. Increased consumption of whole grain foods associated with decreased risk of stroke
10. Increased risk of wheeze and asthma in young children whose mothers smoke during the pregnancy
11. Increased production of antibiotics in space reported by University of Colorado researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... Advancements in biometrics will radically ... wellbeing (HWW), and security of vehicles by ... vehicles begin to feature fingerprint recognition, iris ... monitoring, brain wave monitoring, stress detection, fatigue ... detection. These will be driven by built-in, ...
(Date:12/15/2016)... 14, 2016 "Increase in mobile transactions is ... mobile biometrics market is expected to grow from USD ... 2022, at a CAGR of 29.3% between 2016 and ... the growing demand for smart devices, government initiatives, and ... "Software component is expected to grow at a high ...
(Date:12/8/2016)... India , Dec. 8, 2016 Market Research Future ... Service Market. The global Mobile Biometric Security and Service Market is ... 2016 to 2022. Market Highlights: ... , , Mobile ... pace due to the increasing need of authentication and security from ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... PUNE, India , Jan. 19, 2017  Market Research Future ... The Global Market for Liquid Biopsy is growing rapidly and expected ... period. Market Highlights ... The Global Liquid Biopsy Market has been assessed as ... high growth figures and boom in the coming future. There has ...
(Date:1/19/2017)... Research and Markets ... announced the addition of the "Implantable Biomaterials Market ... report to their offering. Report Highlights: ... analysis on current and future market trends to identify the investment opportunities ... the base numbers Key market trends across the business ...
(Date:1/19/2017)... Md. and GAITHERSBURG, Md. ... (NYSE MKT: PIP) and Altimmune, Inc., a privately-held ... signing of a definitive agreement for the merger ... Altimmune,s current investors include Novartis Venture Fund, HealthCap, ... will be a fully-integrated and diversified immunotherapeutics company ...
(Date:1/19/2017)... ... 2017 , ... The American Medical Informatics Association (AMIA) today ... Policy. Specifically, the nation’s leading informatics experts, said data sharing plans should be ... recommended that NIH earmark funding for researchers to produce and execute data sharing ...
Breaking Biology Technology:
Cached News: