HOME >> BIOLOGY >> NEWS
Increased bone mass in a calcitonin knockout mouse full of surprises

Find below one highlighted articles and the full Table of Contents for the December 16 issue.

****************************************************

Increased bone mass in a calcitonin knockout mouse full of surprises

Bone is in a constant state of remodeling, during which osteoclasts remove old bone (resorption) and osteoblasts form new bone (formation). Calcitonin is a hormone produced by the thyroid gland and inhibits bone resorption. Following menopause, the rate of bone loss is accelerated, however women with post-menopausal osteoporosis that are treated with calcitonin (by injection or nasal spray) demonstrate increased bone mass and strength, in addition to a decrease in the rate of bone fractures. Following alternative processing, the gene encoding calcitonin (CT/CGRP) also encodes a second peptide: calcitonin gene-related peptide-a (CGRPa), however the role of this peptide in bone metabolism has not been clearly defined.

To better understand the role of calcitonin and CGRP-a in bone metabolism Robert Gagel and colleagues at the University of Texas M.D. Anderson Cancer Center, USA, created mice in which the CT/CGRP gene had been deleted. Given that both calcitonin and CGRP have been shown to inhibit bone resorption and CGRP is known to stimulate bone formation, the authors predicted that there would be either no effect of this deletion on bone mass, or there could be some bone loss.

In the December 16 issue of the Journal of Clinical Investigation, the authors report their surprising finding that CT/CGRP-deficient mice have greater bone mass, increased bone formation, and were able to maintain bone mass during estrogen deficiency by increasing bone formation. These findings suggest an important and novel function for the products of the CT/CGRP gene, that was previously unrecognized. They also suggest that the development of an antagonist to the CT/CGRP gene product(s)
'"/>

Contact: Brooke Grindlinger, Ph.D.
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-Dec-2002


Page: 1 2

Related biology news :

1. Increased atmospheric carbon dioxide promotes algal growth
2. Increased temperature may prevent winter flounder from rebounding in east coast estuaries
3. Get your blood moving: Increased blood flow could lead to healthier blood vessels
4. Increased fiber curbs appetite in women
5. Increased CO2 levels are mixed blessing for agriculture
6. Increased awareness of stroke symptoms could dramatically reduce stroke disability
7. Increased use of chemicals in agriculture worldwide seen as major environmental threat
8. Increased consumption of soy protein may help lower cholesterol
9. Increased consumption of whole grain foods associated with decreased risk of stroke
10. Increased risk of wheeze and asthma in young children whose mothers smoke during the pregnancy
11. Increased production of antibiotics in space reported by University of Colorado researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
(Date:3/20/2017)... , March 20, 2017 At this year,s ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand ... is this year,s CeBIT partner country. At the largest German biometrics ... in use: fingerprint, face and iris recognition as well as DERMALOG´s multi-biometrics ... ...
(Date:3/9/2017)... SAN FRANCISCO and MOUNTAIN VIEW, ... Zipongo , "Eating Well Made Simple," and 23andMe ... to help guide better food choices.  Zipongo can now ... only their food preferences, health goals and biometrics, but ... to certain food choices. Zipongo,s personalized food ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Eli Lilly and ... 2 data evaluating galcanezumab for the prevention of migraine ... which will take place April 22-28, 2017, in ... present four abstracts at AAN, including safety and patient ... factors associated with a reduction in monthly migraine headache ...
(Date:4/20/2017)... Maine (PRWEB) , ... April 20, 2017 , ... ... contributions to the scientific and clinical research community’s growing body of knowledge during ... 2017 in the Gracie Theatre and the adjacent Darling Atrium. During the event, ...
(Date:4/20/2017)... - Prometic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("Prometic" or ... Congress ("ILC") 2017 of the European Association for the Study ... on the positive effects of PBI-4050 on reduction of non-alcoholic ... syndrome. ... Lyne Gagnon, Vice-President of R&D Pre-clinical of Prometic "This extensive ...
(Date:4/20/2017)... ... ... Parallel6™ , the leader in mClinical™ technologies for improving patient enrollment, ... of the 2017 Top 10 eClinical Trial Management Solution Providers by Pharma Tech ... take pride in honoring Parallel6 as one of the top 10 companies that are ...
Breaking Biology Technology:
Cached News: