HOME >> BIOLOGY >> NEWS
Increased bone mass in a calcitonin knockout mouse full of surprises

Find below one highlighted articles and the full Table of Contents for the December 16 issue.

****************************************************

Increased bone mass in a calcitonin knockout mouse full of surprises

Bone is in a constant state of remodeling, during which osteoclasts remove old bone (resorption) and osteoblasts form new bone (formation). Calcitonin is a hormone produced by the thyroid gland and inhibits bone resorption. Following menopause, the rate of bone loss is accelerated, however women with post-menopausal osteoporosis that are treated with calcitonin (by injection or nasal spray) demonstrate increased bone mass and strength, in addition to a decrease in the rate of bone fractures. Following alternative processing, the gene encoding calcitonin (CT/CGRP) also encodes a second peptide: calcitonin gene-related peptide-a (CGRPa), however the role of this peptide in bone metabolism has not been clearly defined.

To better understand the role of calcitonin and CGRP-a in bone metabolism Robert Gagel and colleagues at the University of Texas M.D. Anderson Cancer Center, USA, created mice in which the CT/CGRP gene had been deleted. Given that both calcitonin and CGRP have been shown to inhibit bone resorption and CGRP is known to stimulate bone formation, the authors predicted that there would be either no effect of this deletion on bone mass, or there could be some bone loss.

In the December 16 issue of the Journal of Clinical Investigation, the authors report their surprising finding that CT/CGRP-deficient mice have greater bone mass, increased bone formation, and were able to maintain bone mass during estrogen deficiency by increasing bone formation. These findings suggest an important and novel function for the products of the CT/CGRP gene, that was previously unrecognized. They also suggest that the development of an antagonist to the CT/CGRP gene product(s)
'"/>

Contact: Brooke Grindlinger, Ph.D.
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
17-Dec-2002


Page: 1 2

Related biology news :

1. Increased atmospheric carbon dioxide promotes algal growth
2. Increased temperature may prevent winter flounder from rebounding in east coast estuaries
3. Get your blood moving: Increased blood flow could lead to healthier blood vessels
4. Increased fiber curbs appetite in women
5. Increased CO2 levels are mixed blessing for agriculture
6. Increased awareness of stroke symptoms could dramatically reduce stroke disability
7. Increased use of chemicals in agriculture worldwide seen as major environmental threat
8. Increased consumption of soy protein may help lower cholesterol
9. Increased consumption of whole grain foods associated with decreased risk of stroke
10. Increased risk of wheeze and asthma in young children whose mothers smoke during the pregnancy
11. Increased production of antibiotics in space reported by University of Colorado researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/11/2017)... -- NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" ... of independent Directors Mr. Robin D. Richards and ... furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer ... guidance and benefiting from their considerable expertise as we move ...
(Date:4/5/2017)... NEW YORK , April 5, 2017 ... security, is announcing that the server component of the ... is known for providing the end-to-end security architecture that ... customers. HYPR has already secured over 15 ... system makers including manufacturers of connected home product suites ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... ... technology applications, has announced a facility expansion to accommodate its rapid growth. , ... of new workspace and renovation of the existing areas. The expansion includes, a ...
(Date:5/23/2017)... ... , ... Bacterial biofilms, surface adherent communities of bacteria that are encased in ... poisoning and catheter infections to gum disease and the rejection of medical implants. ... per year, there is currently a paucity of means for preventing their formation or ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... re-engineer their control technology again and again. METTLER TOLEDO has released two new ... The videos illustrate how integration of the ACT350 into Siemens and Allen Bradley ...
(Date:5/22/2017)... ... May 22, 2017 , ... Baltimore biotech firm, PathSensors, ... Biohealth community in developing and issuing recommendations to grow Maryland's biohealth industry and ... by 2023. , The recommendations are contained in a report ...
Breaking Biology Technology:
Cached News: