Induced Mutant Mouse Models Of Lipoprotein Disorders And Atherosclerosis

Presentation by Jan L. Breslow, M.D., Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY., at AAAS symposium on "Gene-Diet Interactions in Coronary Heart Disease"

The mouse has become a highly useful model for the study of lipoprotein disorders and atherosclerosis. Although the mouse lipoprotein pattern is dissimilar from that of the human, through induced mutations all of the abnormal lipoprotein phenotypes in humans that are associated with atherosclerosis susceptibility have been produced in the mouse.

This has provided insights into the genes possibly responsible for these disorders in humans and has allowed more invasive studies of the pathophysiology of these disorders. The mouse as a species is highly resistant to atherosclerosis. However, several of the dislipidemias produced in the mouse have resulted in a pattern of atherosclerosis resembling what occurs in humans.

These animal models are being used to study the pathophysiology of lesion formation and the influence of candidate genes on atherosclerosis susceptibility.

Breeding the atherosclerosis prone traits onto different mouse strains has revealed large background effects, and quantitative trait locus mapping has begun to identify the differences between the strains in atherosclerosis susceptibility and resistance genes.

Finally, the mouse atherosclerosis models are being used to examine nutritional and pharmacological effects on lesion formation and progression.

Note to reporters: This is one of four fact sheets about the symposium presentation. News release also available. Contact: 214-706-1340.


Contact: Cathy Yarbrough
American Heart Association

Page: 1

Related biology news :

1. The Chemical Leupeptin Protects Against Noise-Induced Hearing Loss In Animal Model, UB Hearing Researchers Show
2. Millennium Clones Diet-Induced Obesity Gene
3. Ecological Consequences Of Jasmonate-Induced Responses For Plants In Native Populations
4. Inhibition Of A Novel Gene Involved In Phosphorylating Starch In TransgenicPotato Tubers Leads To The Repression Of Cold Induced Sweetening
5. Plants Thrive With Insect-Induced Immune Responses
6. Mutant mice lead to memory insights
7. Mutant biological machine makes proteins but cant let go
8. Mutant gene linked to obsessive compulsive disorder
9. Mutant gene found to cause early ovarian failure in mice
10. Mutants from a lowly weed may solve maladies
11. Mutant proteins may be key to defeat chemical warfare

Post Your Comments:

(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: