Inflammation, hypertension are focus of major new MCG research program

Understanding the relationship between small proteins that regulate inflammation and the big problem of hypertension is the focus of a major new research program at the Medical College of Georgia. An $11 million, five-year grant from the National Heart, Lung and Blood Institute of the National Institutes of Health will help MCG researchers determine if there is a direct cause-and-effect relationship between the two, a finding that could open the door for a new approach to treating hypertension.

"We know there is a correlation between low levels of pro-inflammatory mediators, called cytokines, and high blood pressure," said Dr. R. Clinton Webb, chair of the MCG Department of Physiology and principal investigator on the new NIH Program Project grant. "But we want to know what role these cytokines play in blood pressure elevation and hypertension."

The result could be new, direct targets for treating high blood pressure, a problem that the American Heart Association says affects one in four American adults and is a major risk factor for heart disease.

The first link between inflammatory mediators and heart attacks came with a study published in 1997 in the New England Journal of Medicine by Harvard University's Dr. Paul Ridker correlating higher levels of one element of the inflammatory cascade - the increasingly well-known C-reactive protein - with heart attacks. More recently, Dr. Ridker's group found that higher blood levels of the mediator interleukin-6 - which goes up in inflammation and actually stimulates C-reactive protein - correlates with higher blood pressure. Many physicians now prescribe a daily baby aspirin for those concerned about heart disease and have begun testing C-reactive protein levels to help predict a patient's risk for heart attack.

"Right now, there is a lot of correlation if you look at the literature between C-reactive proteins, interleukin-6, correlations between a lot of inflammatory markers and cardiovascular disea

Contact: Toni Baker
Medical College of Georgia

Page: 1 2 3 4 5

Related biology news :

1. Vioxx in high doses causes hypertension
2. New pulmonary hypertension guideline challenges use of common medication
3. Sex-specific differences in gene expression related to drug metabolism and hypertension
4. Obesity and hypertension: Two epidemics or one?
5. Does a new hypothesis help explain higher levels of hypertension among African-Americans?
6. New study shows why hypertension affects black males disproportionately
7. Non-drug treatment for hypertension found effective in hard-to-control refractory hypertensives
8. Deciphering how arteries contribute to hypertension
9. Grape seed extract may be useful supplement to blunt hypertension in postmenopausal women
10. Study identifies hypertension patients who can benefit from the little used diuretic amiloride
11. Americans lack knowledge of ocular hypertension

Post Your Comments:

(Date:3/5/2020)... ... 2020 , ... In September 2016, stem cell biotechnology company ... the first, and still only, available technology that provides the cell-specific count or ... about the number and quality of therapeutic tissue stem cells are unable to ...
(Date:3/3/2020)... ... March 03, 2020 , ... Amplify Surgical, Inc., today announces that the company ... System. , The landmark case was performed by Dr. Ali Najafi at ... noted, “dualX has completely changed the game for expandable interbodies. The ability to ...
(Date:3/2/2020)... CHICAGO (PRWEB) , ... March 02, 2020 , ... ... attendance at the 71st annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy ... in Chicago, Illinois. Pittcon is the world’s leading annual conference and exposition on ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... Ontario (PRWEB) , ... February 20, 2020 , ... In ... GMT/UK) join guest speakers from Synteract including Lisa Dilworth, BS, MS, Vice ... discussion about these challenges, with feasible strategies and solutions to support patients, sites and ...
(Date:2/19/2020)... ... 2020 , ... Shoreline Biome, a microbiome research ... recently unveiled a novel DNA isolation product. , Shoreline Rapid Prep is a ... weight (HMW) single-stranded DNA (ssDNA) in excess of 40 kB from Gram-negative bacteria, ...
(Date:2/11/2020)... ... February 11, 2020 , ... Synagro ... North America, today announced that the City of Fort Worth has partnered with ... needs. Commencing in April of 2020, Synagro will assume operation of the city’s ...
(Date:2/3/2020)... (PRWEB) , ... February 03, 2020 , ... ... offices in Cambridge, MA, announce that OmniType, the 11-locus, single tube multiplex successor ... OmniType is a best-in-class product featuring locus-multiplexing and short library preparation, for HLA ...
Breaking Biology Technology:
Cached News: