(June 28, 2004) Bethesda, MD Concurrent with the national obesity epidemic has been a rise in the discoveries about how the body controls appetite and food intake. In many of the new findings, research has identified a close relationship between the gastrointestinal endocrine system and the brain in regulating food intake. The relationship is expressed in coordination where circulating hormones convey information about food intake and appetite to brain pathways that control eating.

A team of researchers has added to this knowledge through their investigation of cholecystokinin (CCK) and glucagon-like-peptide-1 (GLP-1), two pre-absorptive signals that indicate when the appetite is satisfied ("satiety"). Both peptides are classical gastrointestinal hormones that are released into the circulation in response to meal consumption. Earlier research has documented that these peptides participate in controlling the appetite in healthy volunteers, and also in patients with obesity or Type II diabetes.

To further explore potential interactions between these two well-known satiety signals, the research team has examined the effects of CCK-33 and GLP-1 and the hormones' interaction in the control of food intake and satiety in healthy subjects. The authors of the study, "Interaction between GLP-1 and CCK-33 in Inhibiting Food Intake and Appetite in Men," are Jean-Pierre Gutzwiller, Lukas Degen, Daniel Matzinger, Sven Prestin, and Christoph Beglinger, all from the University Hospital, Basel, Switzerland. Their research appears in the Articles in PresS section of the American Journal of Physiology Regulatory, Integrative and Comparative Physiology. The journal is one of 14 journals published monthly by the American Physiological Society (http://www.the-aps.org).

Methodology

Twenty-four male volunteers completed the study (mean age 23 years, range 21-29 years, BMI 23.20.8). Inclusion criteria were BMI
'"/>


29-Jun-2004

Page: 1 2 3
Related biology news :

1. Study suggests insect-derived antimicrobial peptides could be used as drug-delivery vehicles
2. Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
3. Patients with serious kidney disorder produce natriuretic peptides at above average rates
4. Antimicrobial peptides: new weapons to fight infection
5. Clearing the brain of amyloid peptides
6. Alzheimers disease is not accelerated aging
7. UNC research accelerates discovery of novel gene function
8. UCSB discovery may accelerate new treatment for global health problem
9. NIH announces strategy to accelerate medical research progress
10. Genetic engineering accelerates the impact of biotechnology on chemical production
11. Studies of genes in mice and common worm may accelerate research on blood diseases, cancers