Inhibitor Shows Potential To Protect Infant Brain

St. Louis, April 27, 1998 -- Several biotech companies are exploring the idea that compounds called caspase inhibitors might minimize the brain damage that results from blood and oxygen shortage. Now researchers at Washington University School of Medicine in St. Louis have shown that one such compound protects newborn rats from damage.

"To our knowledge, this is the first demonstration that delayed treatment with a caspase inhibitor, even when given systemically, can be neuroprotective in an injury model," says David M. Holtzman, M.D., chief author and assistant professor of neurology and molecular biology & pharmacology. "If these compounds prove not to be toxic and are able to come into clinical use, it appears there may be a window of at least several hours when one could administer them."

The findings are published in the May 1 issue of Journal of Clinical Investigation. Former postdoctoral fellow Yu Cheng, M.D., Ph.D., is first author.

An interruption in the supply of blood and oxygen to the brain in the womb or during or after birth is the largest contributor to brain degeneration in children. Life-time consequences include mental retardation, seizures and cerebral palsy, which affects 500,000 Americans.

Holtzman mimics the condition by interrupting the blood supply to one side of a newborn rat's brain and briefly lowering the oxygen content of the air. This procedure kills neurons, which results in loss of brain tissue. Holtzman and colleagues showed, however, that while some neurons swell up and burst, as happens rapidly in adults with head injury or stroke, many neurons slowly shrink through a process resembling cell suicide.

A series of genetically programmed steps lead to cell suicide or apoptosis. The rat brain cells appeared to die this way because their demise was delayed, beginning six hours after the procedure and peaking between 18 and 24 hours. Just before they died, the cells activated their casp

Contact: Linda Sage
Washington University School of Medicine

Page: 1 2 3

Related biology news :

1. Inhibitor of novel cancer target, LPAAT-beta, demonstrates selective anti-cancer effects
2. Natures own medicine for vision loss: Inhibitor of angiogenesis found by biologists at The Scripps Research Institute
3. Research Findings Suggest Potent, Broad-Spectrum Antiviral Activity For Vertexs Investigational IMPDH Inhibitor VX-497
4. Use Of Protease Inhibitors For HIV Associated With Dramatic Rise In Oral Warts
5. How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
6. Cholesterol Inhibitors In Garlic Identified
7. Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
8. New Class Of Protease Inhibitors May Be Effective In Treating One Of Latin Americas Most Devastating Diseases
9. HIV-Positive Injection Drug Users Often Dont Receive Protease Inhibitors And May Not Be Aware Of The Drug
10. New Hampshire Study Shows Well Water Has Higher Arsenic Levels Than Municipal Water
11. New Protein-Like Polymer Shows Promise For Blood Vessel Replacement

Post Your Comments:

(Date:5/2/2019)... , ... April 30, 2019 , ... ... LLP is pleased to announce that Gunes Bender, Ph.D., a registered patent ... sciences practice group. In his new role, Bender provides technical support and scientific ...
(Date:4/27/2019)... ... April 26, 2019 , ... Washington State University’s Center for ... than 30 student venture teams, representing nearly 150 students, presented their business ideas ... The top five teams in the College League were awarded prize money with ...
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Services Secretary Alex Azar today, a broad collective of 62 individual scientists, bioethicists, ... American Society of Gene & Cell Therapy (ASGCT), across industry and academia called ...
Breaking Biology News(10 mins):
(Date:5/8/2019)... ... 2019 , ... Standing at 16.2 hands, Atlas is on the large side for a Quarter ... barrel racing, among other activities. When loping around a corner in late 2017, Atlas ... busy horse to only being able to walk. Fortunately Atlas’ owner, Kelly, sought the ...
(Date:5/2/2019)... S.D. (PRWEB) , ... April 30, 2019 , ... The ... from industrial scale macro breweries to local craft breweries, and even home brewing clubs ... very complex chemical and biological processes, that when mastered can produce a superb product. ...
(Date:4/25/2019)... (PRWEB) , ... April 24, 2019 , ... ... Virtual Agents for sales and service organizations, today announced global availability of ... software providers and enterprises of all sizes to harness the power of ...
(Date:4/12/2019)... ... April 12, 2019 , ... ... neurotechnology and will educate about innovative tools and devices being used to enhance ... for more information. , This segment of Advancements will focus on Sound for ...
Breaking Biology Technology:
Cached News: