HOME >> BIOLOGY >> NEWS
Innovative method for gene therapy of heart disease shows promise in animal studies

Philadelphia, Pa. Heart disease patients may someday receive a dose of gene therapy that would protect injured coronary arteries from further damage and possibly even treat the underlying heart disease. The genes would be delivered to artery walls by stents, the tiny metal scaffolds that are now implanted in diseased arteries to hold the vessels open for improved blood flow.

In cell cultures and in pigs, a team led by a researcher from The Childrens Hospital of Philadelphia showed that genes in DNA added to the stents were transferred into cells on the artery wall. The study appeared in the November issue of the journal Nature Biotechnology.

"This is the first example of gene transfer in an animal model using stents for DNA delivery," said Robert J. Levy, M.D., director of the Pediatric Cardiology Research Laboratory at The Childrens Hospital of Philadelphia. "The technique has major implications for treating coronary artery disease with gene therapy."

Stents are commonly used in angioplasty procedures for partially blocked coronary arteries. After a small balloon is inserted through a catheter and inflated to widen a narrowed artery (the angioplasty procedure), an expandable wire scaffolding (the stent) is left in the artery to keep it open. However, in approximately 30 percent of patients, stents injure the artery, causing cells to grow back within a few months, often forming new obstructions.

The gene delivery technique employed by Dr. Levys team would release a gene or combination of genes that can help control blood vessel damage by inhibiting cell growth in the artery walls. "Further research is needed to identify genes that would have the most beneficial effect," said Dr. Levy, "but this study in animals shows that the gene delivery technique is possible."

Delivery is a crucial problem in any gene therapy approach. Unlike other approaches that uses viruses as delivery vehicles to carry genes into the body, Dr. Levys group uses DNA w
'"/>

Contact: Maria Stearns
stearnsm@email.chop.edu
215-590-4091
Children's Hospital of Philadelphia
7-Nov-2000


Page: 1 2

Related biology news :

1. Innovative ceramic-on-metal hip replacements to undergo clinical trials
2. Innovative efforts target epigenetics, molecular imaging
3. Innovative self healing bandage to help diabetics
4. Innovative shuttle bus debuts in Washington, D.C.
5. Innovative research with pythons offers new insights into the bodys digestive processes
6. Vaccination following spinal cord injury: Innovative Weizmann Institute approach limits paralysis
7. Innovative Process To Benefit Ground Water Clean-Up
8. Exotic Species, Migratory Birds, Sea Level Rise, Wetlands, And Contaminants...USGS Scientists Discuss Innovative Chesapeake Bay Restoration Studies
9. UF Researchers Innovative Fence Helps Control Sand Flies
10. ACS Conference Brief: An Innovative Molecular Assembly
11. Cystic Fibrosis Foundation Launches Innovative Therapeutics Development Centers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/3/2016)... 3, 2016  2016FLEX, organized by FlexTech, a ... advancements in flexible, hybrid and printed electronics. More ... - have gathered for short courses, technical session, ... electronics. The Flex Conference celebrates its 15 th ... R&D organizations, and universities contributing to the adoption ...
(Date:3/2/2016)... , March 2, 2016 ... announced the addition of the  "Global Biometrics ... their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ... to grow at a CAGR of around ... ) has announced the addition of ...
(Date:3/1/2016)... 1, 2016 ... of the  "Global Biometric Access Control ... their offering. --> http://www.researchandmarkets.com/research/ghsgdt/global_biometric ... the  "Global Biometric Access Control Systems ... offering. --> Research and ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... company reports the Company,s CEO  was featured in ... Accelerators Enter When VCs Fear To Tread: ... Leader magazine is an essential business ... everything from emerging biotechs to Big Pharmas. Their ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... an open house for regional manufacturers at its Maple Grove, Minnesota technical center, ... Hardinge Group, Chiron and Trumpf. Almost 20 leading suppliers of tooling, accessories, ...
(Date:4/27/2016)... ... April 27, 2016 , ... Most consumers ... with fingerprint recognition for secure access, voice recognition for hands-free communication, and facial ... are interacting with biometrics technology today. But if they asked Joey Pritikin, ...
(Date:4/27/2016)... , ... April 27, 2016 , ... ... Jon Clark has joined the company as an Expert Consultant. Mr. Clark ... industry collaborations and managing the development of small molecule monographs based on analytical ...
Breaking Biology Technology:
Cached News: