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Innovative method for gene therapy of heart disease shows promise in animal studies

ithin a biodegradable film that coats the metal stents. The technique allows a controlled release of the DNA into cells in the arterial wall, with only minimal spread of the DNA beyond the arteries.

The stent-based technique, says Dr. Levy, may be used in the future for localized gene therapy: the targeted delivery of DNA to a specific site with fewer of the side effects that may occur with systemic gene therapy. Further determination of the most appropriate genes for treating artery disease must occur before the gene-coated stents can be studied in humans.

Co-authors with Dr. Levy are from The Childrens Hospital of Philadelphia and the University of Pennsylvania Medical Center. The study was partially supported by a grant from Selective Genetics, Inc., a biotechnology company in San Diego, Cal. Stents were supplied by the Cordis Corporation of Warren, N.J.


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Contact: Maria Stearns
stearnsm@email.chop.edu
215-590-4091
Children's Hospital of Philadelphia
7-Nov-2000


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