Insight into transplant rejection might lead to novel prevention therapies

ORLANDO, Fla. -- A newly discovered means by which the body attacks transplanted organs might lead to novel methods of preventing the rejection response, research by Duke University Medical Center pulmonologists and transplant surgeons suggests. The finding sheds new light on the role of the innate immune system, the body's first line of defense, in the acute rejection of transplanted lungs.

Drugs targeting the immune reaction could help combat early lung rejection and its complications, thereby increasing patients' chances of survival following the surgery, the researchers said.

Lung transplant recipients with particular variants of a gene called TLR4, which is critical in the lung's defense against bacterial infection, were significantly less likely to suffer acute rejection of the organs, the team found. The researchers presented their results at the 100th International Conference of the American Thoracic Society on May 24, 2004. The work was supported by the National Heart, Lung, and Blood Institute, the National Institute of Environmental Health Sciences, and the Department of Veteran Affairs.

"Those patients with particular variants of the innate immune system gene have a sustained decrease in the frequency and severity of rejection," said Scott Palmer, M.D., medical director of the Duke University Medical Center Lung Transplant Program and lead author of the study. "The finding is consistent with the novel idea that innate immunity regulates the rejection of transplanted lungs."

The innate immune system plays a critical role in combating foreign invaders immediately after infection or exposure, before the body's adaptive immune system can recognize the invasion and launch its attack. While physicians have generally attributed organ transplant rejection solely to the adaptive immune system, the new work indicates an important role for the body's first line of defense, Palmer said.

Acute rejection occurs in 60 percent of

Contact: Kendall Morgan
Duke University Medical Center

Page: 1 2

Related biology news :

1. Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
2. Insights gained from molecular modeling may lead to better insecticides
3. Nerac.com and Infinata partner to offer BioPharm Insight(TM) Resource
4. While the homeland is on alert, Technical Insights provides indispensable technology information
5. Insight into the genetic pathways that drive segmentation like clockwork
6. New Insight into cervical cancer development: turning it up a notch
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UCSF-Led Team Offers New Insight Into Neurological Basis Of Dyslexia
9. New Insights About Good Cholesterol
10. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro
11. Search For Iron Transport Mechanism Leads To "Hephaestus," God Of Metal Working,Who Insight Into Iron-Deficiency Anemia

Post Your Comments:

(Date:8/21/2019)... ... August 20, 2019 , ... ... bioactive technologies for the spine, today announced the 510(K) clearance of its novel ... modification that is proven to improve osseointegration through superior hydrophilicity and optimized surface ...
(Date:8/19/2019)... ... August 19, 2019 , ... Since ... use of ultra-thin two dimensional slices which are placed on microscope slides, stained ... complex tissues and complicated features such as vasculature and thus researchers in the ...
(Date:8/15/2019)... , ... August 15, 2019 , ... ... Now what? As serialization mandates become increasingly complex, and aggregation becomes fully applied ... serialization software is the best long-term solution. , Until now, most regulations?including the ...
Breaking Biology News(10 mins):
(Date:6/26/2019)... ... June 26, 2019 , ... Alice Branton today released research results from ... of Magnesium Gluconate, which can prove to be beneficial for treating Hypomagnesemia. , The ... peak, change in crystallite size , Over 142% increase in particle size ...
(Date:6/18/2019)... , ... June 18, 2019 , ... Personalized Stem ... New Drug (IND) application to the FDA for use of a person’s own adipose-derived ... a treatment of osteoarthritis in the knee. This IND is the first of ...
(Date:6/11/2019)... MONTREAL (PRWEB) , ... June 10, 2019 , ... ... growth of its distribution network with the appointment of Biofeedback Tech Ltd ... physiological monitoring systems are an essential part of many therapeutic treatments and clinical ...
(Date:6/11/2019)... ... June 10, 2019 , ... DeepDyve ... its scientific journals to DeepDyve’s rental service for peer-reviewed journals. , IOPP’s ... of more than 20 million articles, sourced from more than 15,000 journals. , ...
Breaking Biology Technology:
Cached News: