HOME >> BIOLOGY >> NEWS
Insight into transplant rejection might lead to novel prevention therapies

lung recipients despite current immunosuppressive treatments, all of which are directed at the adaptive immune system, he added. Although the initial rejection can in many cases be managed with further treatment, a new suite of drugs aimed at suppressing the innate response in the lung could significantly improve patient outcomes, Palmer said.

The researchers screened 200 transplant recipients and their organ donors for the genetic makeup of TLR4, or "toll-like receptor 4," a key component of innate immunity. Two variants of the gene had earlier been linked to a reduced lung response to bacterial toxins.

Recipients with a single copy of either of those two TLR4 variants exhibited a reduced rate of acute rejection during a period of six months after surgery, the researchers found. Specifically, acute rejection occurred in 28 percent of recipients with the relevant TLR4 variants compared to 58 percent of recipients with more common forms of the gene. The innate immunity genes of the donor had no effect on the chances of rejection, they reported.

The long- and short-term survival of patients after lung transplant lags behind that of other transplanted organs, Palmer said. The new study suggests that the strong innate immune response in the lung might help to explain that difference, he added.

"Innate immunity is critical in the lungs because the organ has to deal constantly with inhalational exposures, including infectious agents and environmental toxins," Palmer said. "Therefore, the lung has an incredible array of innate defenses, including immune cells with receptors like TLR4 built in to recognize and respond to foreign pathogens. Further understanding their role in transplant should greatly enhance physicians' ability to prevent and treat clinical rejection."

The team will conduct additional studies to further elucidate the interaction between the innate and adaptive immune systems following organ transplantation.


'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
24-May-2004


Page: 1 2

Related biology news :

1. Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
2. Insights gained from molecular modeling may lead to better insecticides
3. Nerac.com and Infinata partner to offer BioPharm Insight(TM) Resource
4. While the homeland is on alert, Technical Insights provides indispensable technology information
5. Insight into the genetic pathways that drive segmentation like clockwork
6. New Insight into cervical cancer development: turning it up a notch
7. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
8. UCSF-Led Team Offers New Insight Into Neurological Basis Of Dyslexia
9. New Insights About Good Cholesterol
10. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro
11. Search For Iron Transport Mechanism Leads To "Hephaestus," God Of Metal Working,Who Insight Into Iron-Deficiency Anemia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... An upcoming episode of Advancements ... therapeutics are helping to promote normal immune function in order to prevent and ... about the DECODE.DESIGN.CURE™ technology platform, which rapidly develops microbiome therapeutics in order to ...
(Date:8/14/2019)... ... ... Join Jonathan Riek, PhD, VP, Musculoskeletal & Metabolic Imaging, BioTel Research in ... learn about two common imaging methods in NAFLD/NASH to aid with early disease diagnosis, ... disease, with a worldwide prevalence of 20-46 percent. NAFLD can be subdivided into simple ...
(Date:8/14/2019)... ... August 14, 2019 , ... Gateway Genomics , a ... announces inclusion in the 38th annual Inc. 500|5000 list of fastest growing ... qualify, companies must have been founded and generating revenue by March 31, 2015. Ranking ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... An ... and is scheduled to broadcast 4Q/2019. Check your local listings for more information. ... for generic drug delivery. Focusing on therapeutics for children and the elderly, viewers ...
(Date:8/14/2019)... STATE COLLEGE, Pa. (PRWEB) , ... August 13, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, announced the appointment ... of healthcare industry experience to the Board. , Mark McLoughlin will lend his ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... for sales and service organizations, today announced that the company’s Studio Intelligent Virtual ... the IVA market . Inference will officially accept the award at Frost & ...
(Date:8/6/2019)... ... 06, 2019 , ... The San Diego Biotechnology Network (SDBN) ... SDBN BUZZ podcast focused on connecting the region’s biotech community and discussing topics ... the region and attract external employers, investors, scientists, and others who wish to ...
Breaking Biology Technology:
Cached News: