HOME >> BIOLOGY >> NEWS
Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation

The proteasome is the central enzyme of the ATP-ubiquitin-dependent proteolytic pathway. It is responsible for the elimination of abnormal proteins, arising from mutations or damage ensuing from adverse external conditions. Moreover, it has important regulatory roles in numerous biological processes such as cell cycle, apoptosis or the immune response. A research team at the Max Planck Institute of Biochemistry in Martinsried/Germany, headed by Wolfgang Baumeister, since several years one of the leading groups in the proteasome field, has published a review-article in Cell on February 6, 1998, reflecting on the proteasome as one of the most fascinating macromolecular machines of the cell. The authors report on own data and review the current status of the topic.

Protein degradation is a necessity but also a hazard. It must be subject to precise spatial and temporal control to prevent that proteins not destined for degradation are attacked. A basic strategy in controlling protein degradation is compartmentalization, that is sequestration of proteolytic action from the environment. Many proteases reside within spezialized membrane-surrounded organelles, such as lysosomes. Another mechanism of control, which offers greater logistic flexibility, is self- or autocompartmentalization: proteolytic subunits self-associate into barrel-shaped complexes with inner cavities that harbour the active sites. The advances made in recent years in understanding the structure of the proteasome and its mechanism of action has helped to shape the concept of self-compartmentalization, and the proteasome became its paradigm.

The molecular species that functions in the ubiquitin-proteasome pathway is the so-called 26S proteasome, a large complex composed of approx. 35 different subunits. A smaller particle, the 20S
'"/>

Contact: Erika Seemller
seemuell@biochem.mpg.de
+49-89-8578-2634
Max-Planck-Gesellschaft
2-Mar-1998


Page: 1 2 3 4

Related biology news :

1. Insights on stroke from the peripheral blood suggest ways to develop markers and therapies
2. Insights gained from molecular modeling may lead to better insecticides
3. While the homeland is on alert, Technical Insights provides indispensable technology information
4. New Insights About Good Cholesterol
5. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro
6. UNC-CH Groucho Research Offers Insights Into How Embryo, Cancer Cells Communicate
7. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies
8. Gene Discovery Provides Insights Into Epilepsy
9. Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference
10. Very Fruitful Collaboration Between French And German Scientists Yields Unusual Insights Into The Structure Of Membrane Proteins
11. New Insights Into The Enigma Of Lengthening Longevity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/5/2020)... MURRIETA, Calif. (PRWEB) , ... June 04, 2020 , ... ... , has filed a new patent application for simplified sample preparation for Next ... technology that will greatly reduce cost, time, and complexity of sample preparation. , “I ...
(Date:6/2/2020)... ... June 02, 2020 , ... TEKLYNX ... solutions provider, today reported that the implementation of browser-based, enterprise label management ... resulting in greater efficiency for global biotechnology company, bioMérieux. , Headquartered in ...
(Date:5/28/2020)... INDIANAPOLIS (PRWEB) , ... May 27, 2020 , ... ... of hc1 Workforce Advisor™ , a solution that uniquely combines lab testing ... to help employers systematically support the ongoing health and safety of employees returning ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 2020 , ... In most research using the zebrafish model, ... in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past ... the zebrafish model to investigate the causes of leukaemia and its relationship with ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World has announced the ... Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia ... program, highlighting outstanding examples of how technology innovations and strategic initiatives can be ...
(Date:7/1/2020)... ... June 30, 2020 , ... ... that the launch of a new clinical diagnostics immuno-oncology service, TissueInsight ... microenvironment (TME). , “Flagship’s TissueInsight is a service that aids pathologists, oncologists, ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... for treating cancer, today announced the company has entered a license agreement with ... agreement provides Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a ...
Breaking Biology Technology:
Cached News: