Insights on stroke from the peripheral blood suggest ways to develop markers and therapies

Since scientists can not easily obtain brain tissue biopsies as people are having strokes, the development of rapid, high resolution brain imaging modalities was a big step forward in gaining a better understanding of the onset and progression of these often catastrophic events. Now scientists at the NIH's National Institute of Neurological Disorders and Stroke (NINDS) are combining real-time imaging technology with yet another way of following what happens during a stroke. Using small blood samples taken from patients' arms during and immediately following strokes, the researchers have found white blood cell genetic changes they believe reflect the body's fighting response to the ongoing "brain attack" of an ischemic stroke.

About 80 percent of all strokes (the other 20 percent being hemorrhagic), ischemic strokes occur when the blood vessel is blocked, depriving brain tissue of blood and the oxygen carried by the blood. In a further finding, leaking antigens from the injured brain may stimulate increased numbers of a particularly toxic type of T cell lymphocyte, which can actually precipitate new strokes by causing damage to the lining of the blood vessels.

Dr. Alison Baird, of the NINDS Stroke Neuroscience Unit, presented the study at Experimental Biology 2004, as part of the scientific sessions of the American Association of Anatomists, one of the six sponsoring societies of this year's Experimental Biology meeting.

Dr. Baird says new insights from the peripheral blood into the pathology of stroke and the body's response to stroke may allow the development of surrogate biomarkers of stroke risk and prognosis and give information on new cellular and pathological mechanisms involved in the etiology and response to acute stroke, ultimately leading to new drug therapies or preventive vaccines.

Blood studies are infinitely faster and more practical than looking at brain tissue samples from biopsy or post-mortem, and have the added ad

Contact: Sarah Goodwin
Federation of American Societies for Experimental Biology

Page: 1 2 3

Related biology news :

1. Insights gained from molecular modeling may lead to better insecticides
2. While the homeland is on alert, Technical Insights provides indispensable technology information
3. New Insights About Good Cholesterol
4. New Insights Into The Transport Machinery Of The Cell: A Single Protein Substitutes The Regulatory Machinery Specifying Endosome Fusion In Vitro
5. UNC-CH Groucho Research Offers Insights Into How Embryo, Cancer Cells Communicate
6. New Insights On Sequence of Cell Death After Brain Injury: Understanding Cellular Events After Brain Trauma Could Lead To Better Therapies
7. Gene Discovery Provides Insights Into Epilepsy
8. Fauci To Present New Insights Into HIV Latency At 12th World AIDS Conference
9. Very Fruitful Collaboration Between French And German Scientists Yields Unusual Insights Into The Structure Of Membrane Proteins
10. New Insights Into The Enigma Of Lengthening Longevity
11. Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation

Post Your Comments:

(Date:6/28/2020)... (PRWEB) , ... June 25, 2020 , ... In an ... on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings for ... are collected at medical offices and are shipped to labs throughout the country. Results ...
(Date:6/23/2020)... ... June 23, 2020 , ... Kemp ... announced that the company has received ISO9001:2015 certification for the development and ... industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to a ...
(Date:6/23/2020)... ... , ... The field of quantitation of large molecules or proteins has been ... However, the use of mass spectrometry in this field has gained a lot of ... you choose which approach to use (LBA or MS)?” In many cases, either ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information Solutions Life ... webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). , The ... medical devices, the NMPA has departments dealing with medical device registration (pre-market approvals) and ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... products, announces a significant expansion of laboratory operations through its COVID-19 testing ... implementing testing programs. , Bode-CARES provides a turnkey solution that ...
(Date:7/7/2020)... ... July 06, 2020 , ... ... Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General ... World has hosted an elite awards program, highlighting outstanding examples of how technology ...
(Date:6/28/2020)... ... June 25, 2020 , ... With the COVID-19 pandemic impacting ... treatment. In an effort to better understand the cellular responses to COVID-19, the ... dataset portraying therapeutic compound effects from over 1,600 approved and referenced molecules on ...
Breaking Biology Technology:
Cached News: