HOME >> BIOLOGY >> NEWS
Insulin in heart development

Given the profound effects of insulin on energy metabolism and gene expression in virtually all tissues, it is not surprising that systemic deficiency in the insulin receptor (IR) leads to the early postnatal death of IR?/? mice. However, Cre/lox technology has also allowed for the creation of animals lacking the IR specifically in particular cell types, and the more subtle phenotypes in these designer mice offer deeper insights into the effects of insulin resistance in specific energy-storing or -consuming organs in the adult animal. Thus, skeletal muscle-specific IR knockout (MIRKO) mice have been available for several years, and animals lacking the receptor in pancreatic b islet cells, hepatocytes, or brown adipose cells have all been described. Belke et al. now add to this list the CIRKO mouse, which lacks the IR specifically in cardiomyocytes. In young CIRKO animals, the heart is of normal structure but is reduced in size, apparently because the cells themselves remain small. Indeed, CIRKO cardiomyocytes appear immature in several other respects, particularly their preferential use of glucose, rather than fatty acids, as a metabolic fuel and their continued high expression of the b isoform of the myosin heavy chain, which is normally suppressed after fetal development. Interestingly, one well established effect of insulin in the heart, the activation of glucose oxidation, is maintained in CIRKO animals. The authors speculate that endothelial cells or some other insulin-responsive cardiac cell type is responsible for inducing this metabolic change in the cardiac muscle, perhaps as a secondary effect of enhanced eNOS activity. Testing such a model might require the generation of yet another cell type specific IR knockout mouse, this one targeting the endothelium.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
27-Feb-2002


Page: 1

Related biology news :

1. Insulin-producing pancreatic cells are replenished by duplication
2. Insulin study sheds light on physics of crystal growth
3. Insulin-degrading enzyme may affect risk of Alzheimers disease
4. Insulin in worms
5. In The Genes: Extra Belly Fat, Insulin Resistance Linked
6. Researchers Identify And Isolate First Gene For A Form Of Insulin-Dependent Diabetes
7. Space Grown Insulin Crystals Provide New Data On Diabetes
8. Cellular Short Circuit Causes Insulin Resistance
9. Insulin Resistance Is A Risk Factor For Atherosclerosis In Whites And Hispanics
10. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
11. Screen siblings, parents of infants with severe heart abnormalities

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/5/2019)... ... March 05, 2019 , ... Join this live ... metadata-driven approach will help data analysts and bioinformaticians focus on data analysis without worrying ... that can come from different source systems. Some sources of data include:, ...
(Date:2/27/2019)... ... February 27, 2019 , ... Fluxion Biosciences, a leading developer of precision solutions ... Cancer Institute grant for further development of its ERASE-Seq liquid biopsy technology. The Phase ... lab of Dr. Omar Mian at the Cleveland Clinic. , Liquid biopsies offer the ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... plans today to expand the company’s footprint in Frederick, MD after a year ... used RoosterBio’s adult human mesenchymal stem/stromal cell (hMSCs) products to streamline their product ...
Breaking Biology News(10 mins):
(Date:3/9/2019)... DIEGO (PRWEB) , ... March 07, 2019 , ... ... Technologies, is a pioneer in the development and commercialization of high performance, cutting-edge ... PhysioStim, a leading European CRO with GLP-certified expertise in cardiovascular pharmacology and electrophysiology, ...
(Date:3/5/2019)... Texas (PRWEB) , ... March 05, 2019 , ... ... a biopharmaceutical cold chain engineering firm with regulatory filing authorities, logistics network experts, ... corporate information to initiate its participation in the Inc. Verified Profile program, Inc. ...
(Date:2/27/2019)... ... February 26, 2019 , ... Superior Controls, Inc., a leading ... 140 employees on both the east and west coasts, today announced that employee ... New Hampshire. Sandmaier, a senior project engineer, joins Taggart McCormick, P.E., Anthony Whitesell, ...
(Date:2/22/2019)... ... February 20, 2019 , ... Superior Controls, Inc. ... solutions with 140 employees on both the east and west coasts, today announced the ... working out of the company’s Seabrook, New Hampshire office. In his new role, ...
Breaking Biology Technology:
Cached News: