Intake Of Acetaminophen Increases Risk Of Excessive Anticoagulation In Patients,,Taking Warfarin

People who take the anticoagulant drug warfarin are at increased risk of excessive anticoagulation if they also take large amounts of the pain reliever acetaminophen, according to a study from the Massachusetts General Hospital (MGH). Excessive anticoagulation is known to raise the risk of major hemorrhage. The report appears in the March 4 Journal of the American Medical Association.

"While acetaminophen generally is a very safe drug for pain and fever, continuous use -- for seven days or more -- should prompt closer monitoring of anticoagulation levels to reduce the risk of hemorrhage," says Elaine Hylek, MD, MPH, of the MGH Medical Practices Unit, the paper's first author. Acetaminophen is often the pain reliever of choice for people with potential bleeding problems because aspirin and non-steroidal anti-inflammatory drugs like ibuprofen can cause gastric bleeding.

Warfarin is a blood-thinning drug taken by millions of people with a heart condition called atrial fibrillation to prevent the development of blood clots that could cause strokes. It also is taken to prevent clots around replacement heart valves and to dissolve blood clots in the legs or lungs. Because the drug's effects can be altered by many factors -- including illness, other medications, and eating foods containing vitamin K -- warfarin treatment is a delicate balancing act between two serious risks. Too little anticoagulant effect and the patient could develop a clot that might travel to the brain and cause a stroke, too much anticoagulation and the patient could suffer a major hemorrhage.

Patients on long-term treatment usually have a monthly blood test called the INR (international normalized ratio) to measure their levels of anticoagulation. The MGH team surveyed 289 patients from the hospital's anticoagulation unit within 24 hours of a regular outpatient INR test. Among these patients, 93 had been found to have an INR greater than 6 -- a level associated with increas

Contact: Susan McGreevey
Massachusetts General Hospital

Page: 1 2

Related biology news :

1. Dietary Protein Intake And Risk Of Hip Fracture In Postmenopausal Women
2. Eating Less Fat At One Meal May Lead To Higher Fat Intake Later
3. New Recommended Intake Of Folate, Other B Vitamins, And Choline To Be Announced At April 7 Briefing
4. Adults Need To Increase Intake Of Folate; Some Women Should Take More
5. Infants, Toddlers Should Not Restrict Fat Intake, Experts Say
6. Acetaminophen may protect against heart damage according to Rutgers research
7. Study Suggests Vaccine Increases Survival In Ovarian And Breast Cancer Patients Following High-Dose Chemotherapy And Autologous Stem Cell Transplant
8. Stress Increases Blood Chemical Related To Heart Disease
9. Severe Falciparum Malaria Increases In Honduras
10. Lower Temperature Increases Virus Production
11. Survey Shows Students Turning To Physicians Less As Drug Abuse Increases

Post Your Comments:

(Date:6/16/2019)... ... June 14, 2019 , ... Emtec, Inc.®, a ... a joint presentation with Versiti’s CIO at the Healthcare Industry User Group ... Creek Resort. , Versiti Vice President and Chief Information Officer, Lynne Briggs, will ...
(Date:6/11/2019)... AUCKLAND, New Zealand (PRWEB) , ... June 12, ... ... a wide range of antibody discovery services, Abveris plans to leverage the Geneious ... , Dr. Colby Souders, Chief Technology Officer at Abveris, says: “The Geneious ...
(Date:6/6/2019)... (PRWEB) , ... June 05, 2019 , ... ... role as the exclusive financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its ... a preeminent anatomic pathology platform that provides services to more than one dozen ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... May 30, 2019 , ... World Compliance Seminars today announced ... 2019 in Boston, MA. This peer recommended interactive workshop is always selected by ... will kick off with a compendial treatment of Data Integrity fundamentals. After laying ...
(Date:5/15/2019)... ... ... Milton Hershey School® has named William Charles Ballough Harding ’78 the 2019 ... he is changing lives by creating solutions to global healthcare challenges through the development ... our founders – Milton and Catherine Hershey – who always hoped for Milton Hershey ...
(Date:5/7/2019)... ... 06, 2019 , ... "The new Liquid Nitrogen Best Practices ... asked to store cellular products being used in adoptive therapy research and ... leaders, who have shared their expertise in building and managing facilities to support ...
(Date:5/2/2019)... TORONTO (PRWEB) , ... May 02, 2019 , ... Stay ... pharma, biotech, medical device and food industries. Access to all webinars is free, so ... stay relevant in your field! , Visit http://www.xtalks.com to see our upcoming ...
Breaking Biology Technology:
Cached News: