Intake Of Acetaminophen Increases Risk Of Excessive Anticoagulation In Patients,,Taking Warfarin

People who take the anticoagulant drug warfarin are at increased risk of excessive anticoagulation if they also take large amounts of the pain reliever acetaminophen, according to a study from the Massachusetts General Hospital (MGH). Excessive anticoagulation is known to raise the risk of major hemorrhage. The report appears in the March 4 Journal of the American Medical Association.

"While acetaminophen generally is a very safe drug for pain and fever, continuous use -- for seven days or more -- should prompt closer monitoring of anticoagulation levels to reduce the risk of hemorrhage," says Elaine Hylek, MD, MPH, of the MGH Medical Practices Unit, the paper's first author. Acetaminophen is often the pain reliever of choice for people with potential bleeding problems because aspirin and non-steroidal anti-inflammatory drugs like ibuprofen can cause gastric bleeding.

Warfarin is a blood-thinning drug taken by millions of people with a heart condition called atrial fibrillation to prevent the development of blood clots that could cause strokes. It also is taken to prevent clots around replacement heart valves and to dissolve blood clots in the legs or lungs. Because the drug's effects can be altered by many factors -- including illness, other medications, and eating foods containing vitamin K -- warfarin treatment is a delicate balancing act between two serious risks. Too little anticoagulant effect and the patient could develop a clot that might travel to the brain and cause a stroke, too much anticoagulation and the patient could suffer a major hemorrhage.

Patients on long-term treatment usually have a monthly blood test called the INR (international normalized ratio) to measure their levels of anticoagulation. The MGH team surveyed 289 patients from the hospital's anticoagulation unit within 24 hours of a regular outpatient INR test. Among these patients, 93 had been found to have an INR greater than 6 -- a level associated with increas

Contact: Susan McGreevey
Massachusetts General Hospital

Page: 1 2

Related biology news :

1. Dietary Protein Intake And Risk Of Hip Fracture In Postmenopausal Women
2. Eating Less Fat At One Meal May Lead To Higher Fat Intake Later
3. New Recommended Intake Of Folate, Other B Vitamins, And Choline To Be Announced At April 7 Briefing
4. Adults Need To Increase Intake Of Folate; Some Women Should Take More
5. Infants, Toddlers Should Not Restrict Fat Intake, Experts Say
6. Acetaminophen may protect against heart damage according to Rutgers research
7. Study Suggests Vaccine Increases Survival In Ovarian And Breast Cancer Patients Following High-Dose Chemotherapy And Autologous Stem Cell Transplant
8. Stress Increases Blood Chemical Related To Heart Disease
9. Severe Falciparum Malaria Increases In Honduras
10. Lower Temperature Increases Virus Production
11. Survey Shows Students Turning To Physicians Less As Drug Abuse Increases

Post Your Comments:

(Date:3/5/2020)... ... ... Patients in need of new teeth after tooth extraction or full mouth ... of Ocala. Same-day dental implants allow patients with an entire mouth of ... This treatment utilizes advanced technology and Dr. Brand’s unique experience and skills to provide ...
(Date:3/4/2020)... (PRWEB) , ... March 04, 2020 , ... ... founders and CEOs to apply to the MedTech IGNITE program’s 2020 IGNITE Cohort. ... and networking curriculum to attract and nurture the next generation of medtech founders ...
(Date:3/3/2020)... ... March 03, 2020 , ... Board-certified oral and maxillofacial surgeon, ... over 16 years of training and experience, Dr. Noffze can successfully extract problem and ... as soon as possible is beneficial to the oral and overall health of most ...
Breaking Biology News(10 mins):
(Date:3/3/2020)... ... March 03, 2020 , ... ... biotech and medical device industries, was recognized by INC. 5,000 on an annual ... lists to note industry leaders greatly impacting their spheres of influence and experiencing ...
(Date:2/28/2020)... SAN DIEGO (PRWEB) , ... February 26, 2020 ... ... HS7 system combines a high-speed camera with a dedicated controller, thus ... 2500 frames per second, the HS7 is the first of Fastec Imaging’s new ...
(Date:2/21/2020)... ... February 20, 2020 , ... ... and elegant chemistry. Humans have been increasingly successful in innovating ways to ... rapidly evolving technologies and strategies for modern molecular biology (e.g., gene sequencing, ...
(Date:2/21/2020)... ... February 21, 2020 , ... Pharmaceutical manufacturers ... in order to adapt to new approaches like ‘Industry 4.0’ and continuous manufacturing, ... for personalized medicine and therapies. But with an industry with the world’s tightest ...
Breaking Biology Technology:
Cached News: