HOME >> BIOLOGY >> NEWS
Interleukin-12 Helps Control Mycobacterium Avium Infection

Scientists at the National Institute of Allergy and Infectious Diseases (NIAID) have found that treating mice with interleukin-12 (IL-12) plus conventional antibiotic therapy can help control infection with Mycobacterium avium, an opportunistic infection common in people with late-stage AIDS. IL-12, a cytokine or chemical messenger produced by immune cells, helps regulate cell-mediated immunity.

These findings in immunodeficient mice suggest that combined IL-12/drug treatment may offer a highly effective strategy for managing atypical mycobacterial infections in people who have AIDS or are otherwise immunocompromised, note Mark Doherty, Ph.D., and Alan Sher, Ph.D., of NIAID's Laboratory of Parasitic Diseases, in their report published June 1 in the The Journal of Immunology. Furthermore, they postulate that the same approach might work for other opportunistic infections common in these individuals such as Toxoplasma and Histoplasma. Previous research in animals has shown that these infections also respond to IL-12 treatment.

Based on the new findings, researchers at the National Institutes of Health led by Henry Masur, M.D., recently began recruiting people with both AIDS and Mycobacterium avium complex (MAC) into a Phase I clinical trial to test IL-12 in combination with standard antibiotic treatment regimens. MAC is an infection caused by either M. avium or its close relative, M. intracellulare.

"This is an excellent example of how a preclinical study can provide a model for designing a clinical trial," says Anthony S. Fauci, M.D., director of NIAID.

"It's very difficult to treat this infection in AIDS patients," comments Dr. Sher. Often patients have to be treated with three or four different drugs, which can have toxic side effects so that patients become intolerant to one or more drugs. Furthermore, the bacteria that causes the infection can become resistant to one or more antibiotics. This protocol is evaluating a way we might enh
'"/>

Contact: Laurie K. Doepel
ldoepel@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
1-Jun-1998


Page: 1 2 3

Related biology news :

1. Software Helps Decipher Genomes Of Higher Organisms
2. Nutrition Therapy Helps Patients Emotionally, Research Shows
3. ASU Professor Helps In Fight To Protect Japanese Pika Habitat
4. Whitehead Study Supports Existence Of Ancient RNA World, Helps Provide Insight Into Early Evolution Of Life
5. Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction
6. Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke Researchers Say
7. Security Code Helps Immune Cells Attack Foe And Spare Self
8. NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
9. Auditory Scene Analysis Helps Find Mates
10. UF Researchers Innovative Fence Helps Control Sand Flies
11. Purdue Research Helps Keep Phosphorus Out Of Surface Water

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
(Date:3/23/2017)... PUNE, India , March 23, 2017 The report ... Equipment, Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by ... growing at a CAGR of 29.63% between 2017 and 2022. ... ... Logo ...
(Date:3/22/2017)... 2017 Optimove , provider of ... such as 1-800-Flowers and AdoreMe, today announced two ... Replenishment. Using Optimove,s machine learning algorithms, these features ... replenishment recommendations to their customers based not just ... customer intent drawn from a complex web of ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... RoviSys, a leading independent ... the opening of an office in Taipei, Taiwan. This new location allows RoviSys ... developing new relationships in the region. Located in the Neihu area of Taipei, ...
(Date:9/19/2017)... ... September 19, 2017 , ... VetStem Biopharma ’s CEO and founder, Dr. Bob Harman ... Riordan’s new book "Stem Cell Therapy: A Rising Tide". Dr. Harman and Dr. Riordan ... bonded over an interest in the potential of stem cell therapy and a fast friendship ...
(Date:9/19/2017)... ... September 19, 2017 , ... Avomeen Analytical ... recipients of its 2017 Science Student Award. The scholarship program is dedicated to ... community service defray the costs of obtaining their science education. , Avomeen began ...
(Date:9/18/2017)... ... September 18, 2017 , ... ... to produce biochar, briquettes, and torrefied wood is the topic of a ... To characterize the potential economic viability of transportable biomass conversion facilities for producing ...
Breaking Biology Technology:
Cached News: