HOME >> BIOLOGY >> NEWS
Interleukin-12 Helps Control Mycobacterium Avium Infection

Scientists at the National Institute of Allergy and Infectious Diseases (NIAID) have found that treating mice with interleukin-12 (IL-12) plus conventional antibiotic therapy can help control infection with Mycobacterium avium, an opportunistic infection common in people with late-stage AIDS. IL-12, a cytokine or chemical messenger produced by immune cells, helps regulate cell-mediated immunity.

These findings in immunodeficient mice suggest that combined IL-12/drug treatment may offer a highly effective strategy for managing atypical mycobacterial infections in people who have AIDS or are otherwise immunocompromised, note Mark Doherty, Ph.D., and Alan Sher, Ph.D., of NIAID's Laboratory of Parasitic Diseases, in their report published June 1 in the The Journal of Immunology. Furthermore, they postulate that the same approach might work for other opportunistic infections common in these individuals such as Toxoplasma and Histoplasma. Previous research in animals has shown that these infections also respond to IL-12 treatment.

Based on the new findings, researchers at the National Institutes of Health led by Henry Masur, M.D., recently began recruiting people with both AIDS and Mycobacterium avium complex (MAC) into a Phase I clinical trial to test IL-12 in combination with standard antibiotic treatment regimens. MAC is an infection caused by either M. avium or its close relative, M. intracellulare.

"This is an excellent example of how a preclinical study can provide a model for designing a clinical trial," says Anthony S. Fauci, M.D., director of NIAID.

"It's very difficult to treat this infection in AIDS patients," comments Dr. Sher. Often patients have to be treated with three or four different drugs, which can have toxic side effects so that patients become intolerant to one or more drugs. Furthermore, the bacteria that causes the infection can become resistant to one or more antibiotics. This protocol is evaluating a way we might enh
'"/>

Contact: Laurie K. Doepel
ldoepel@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
1-Jun-1998


Page: 1 2 3

Related biology news :

1. Software Helps Decipher Genomes Of Higher Organisms
2. Nutrition Therapy Helps Patients Emotionally, Research Shows
3. ASU Professor Helps In Fight To Protect Japanese Pika Habitat
4. Whitehead Study Supports Existence Of Ancient RNA World, Helps Provide Insight Into Early Evolution Of Life
5. Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction
6. Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke Researchers Say
7. Security Code Helps Immune Cells Attack Foe And Spare Self
8. NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
9. Auditory Scene Analysis Helps Find Mates
10. UF Researchers Innovative Fence Helps Control Sand Flies
11. Purdue Research Helps Keep Phosphorus Out Of Surface Water

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Interleukin Helps Control Mycobacterium Avium Infection

(Date:6/24/2015)... Biometry authentication provider KeyLemon today announced ... one face in. Logo - ... in, entering the expanding biometric authentication market in ... answer to the password problem. With advanced face ... KeyLemon, one face in allows users to securely ...
(Date:6/23/2015)... BEACH GARDENS, Fla. , June 23, ... multi-factor identity management and authentication solutions, today announced ... Altus strong, multi-factor authentication solution.  The enhancements ... of use of the DigitalPersona Altus platform ... biometric reader compatibility. In today,s ...
(Date:6/17/2015)... , June 17, 2015 QIAGEN ... launched new Investigator ® STR assay kits for analysis ... United States . The new genetic fingerprint kits provide ... (short tandem repeats or STRs) for DNA matching. They incorporate ... of DNA in each sample, a novel QIAGEN technology that ...
Breaking Biology News(10 mins):KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5
(Date:7/2/2015)... PALO ALTO, Calif. (PRWEB) , ... July 02, 2015 , ... ... designed to improve an individual’s quality of sleep, launched its Indiegogo campaign on June ... and functionality: Luzi's voice command technology makes it effortless to use, while the integration ...
(Date:7/1/2015)... , ... July 01, 2015 , ... It is now ... (TBI) using single photon emission computed tomography (SPECT) according to researchers from ... which examined over 20,000 brain scans and is believed to be the largest brain ...
(Date:7/1/2015)...   Decision Resources Group finds that ... are its oral administration, alternative mechanism of action, ... rheumatologists. Otezla was the first oral therapy specifically ... psoriatic arthritis in the United States ... conventional oral treatments including disease-modifying antirheumatic drugs (DMARDs), ...
(Date:7/1/2015)... and BANGALORE, India , July 1, ... company that uses next generation sequencing technology to empower ... A. Storrer as chief executive officer. In his ... be responsible for all strategy, business expansion and worldwide ... has served as Strand,s chairman and CEO since its ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3
Cached News: