"As the aging population continues to grow, there is an urgent need to develop identification and treatment methods for intraepithelial neoplasia," said Scott Lippman, M.D., of the M.D. Anderson Cancer Center, Houston, Tex.
"We are hoping studies, like the data presented today, will continue to advance our knowledge and bring us closer to early screening methods for these deadly diseases," he added.
Correlation of Proliferation, Apoptosis and Nuclear and Glandular Features with Development of Prostatic Intraepithelial Neoplasia (PIN) and Prostate Cancer (Abstract 1255)
Researchers at the Roswell Park Cancer Institute, Buffalo, NY, and the University of Arizona Cancer Center in Tucson examined several factors that may be important in the development of prostate cancer, including nuclear and glandular features of prostate tissue, cell proliferation (reproduction) and cell apoptosis (cell death). Many studies have suggested that high-grade prostatic intraepithelial neoplasia (HGPIN, abnormal growth in the glands or ducts of the prostate) is a precursor to prostate cancer, and it has been recommended as a significant target for prostate cancer chemoprevention. As the most frequently diagnosed cancer in the United States and the second leading cause of cancer death for men, prostate cancer receives much attention, and prevention methods are in high demand.
Researchers distinguished abnormalities in cell changes in four different tissue diagnoses: normal cells, low grade PIN
Contact: Aimee Frank
American Association for Cancer Research