HOME >> BIOLOGY >> NEWS
Intrakine blockade of a chemokine receptor

In one clever but still unproved scheme for blocking the progression of AIDS, a so-called "intrakine" is to be transduced into lymphocytes to prevent surface expression of a molecule required for HIV entry. Infection by HIV depends in part on the surface protein CXCR4, a receptor whose endogenous ligand is the chemokine SDF-1. Earlier work showed that an engineered SDF-1 variant that is retained in the endoplasmic reticulum has a dominant effect on CXCR4, preventing the receptor from reaching the cell surface and thus rendering the cell resistant to HIV. Clinical tests of this approach are ongoing, but meanwhile Zeelenberg and colleagues have used the same system to examine other cellular effects of loss of CXCR4 surface expression. They show here that T lemphocyte-derived hybridomas--usually an invasive cell type that can cross multiple barriers to reach target organs-- lose their ability to migrate in response to SDF-1. These transfected hybridomas fail to cross cell monolayers in culture or to exit the bloodstream when introduced in vivo. A control intrakine that blocks surface expression of a different chemokine receptor, CCR4, does not affect the ability of these cells to disseminate or generate malignant tumors, indicating that SDF-1 signaling is specifically required for invasive behavior by these cells. Whether normal T cells also depend on the SDF-1/CXCR4 interaction to reach their target tissues is not clear, but if so, the SDF-1 intrakine strategy for treating AIDS may prove to be immunosuppressive in its own right.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
11-Jul-2001


Page: 1

Related biology news :

1. Ovarian cancer sheds tumor suppression with loss of estrogen receptor
2. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
3. Two-pronged attack targeting EGF receptor hinders cancer cell growth
4. Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
5. Dioxin-receptor network identified
6. Inhibition of insulin-like growth factor receptor-1 as promising anticancer therapeutic
7. Scientists at Scripps Research Institute describe structure of receptor on surface of 1918 flu virus
8. Activation of receptor ups development of precancerous intestinal polyps
9. Researchers find an association between alcohol dependence and the GABAA receptor gene GABRG3
10. The dopamine receptor D1 gene and ADHD: A piece of the genetic puzzle?
11. Estrogen receptor-a disruption and vasodilation in coronary arteries

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/3/2019)... ... October 01, 2019 , ... The CHEM+POUR ... reagents, and medias and to be a more environmentally sustainable evolution to plastic ... years of experience and feedback from the original version we launched in September ...
(Date:9/30/2019)... ... September 30, 2019 , ... ... increasing the capacity of life science organizations to accelerate innovation and maximize productivity, ... on October 4th. , What: Just 30 days to 21 CFR Part 11 ...
(Date:9/25/2019)... (PRWEB) , ... September 25, 2019 , ... ... in Austin, TX, have placed over 20,000 dental implants for a variety of ... highly technical zygomatic and pterygoid dental implants. Dental implants offer patients ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia Corporation, the global ... today announces that the U.S. Food and Drug Administration (FDA) has granted the ... temporary relief of chronic neck and shoulder pain of musculoskeletal origin. , Erchonia ...
(Date:10/3/2019)... , ... October 01, 2019 , ... Cheyenne is a ... Mimi, Cheyenne’s owner, owns and operates Rebel’s Run , which offers riding ... favorite amongst students and trail riding guests. Mimi describes her as her “go ...
(Date:10/3/2019)... ... October 02, 2019 , ... eKare’s inSight® digital 3D imaging and wound ... by the East Midlands Academic Health Science Network (EMAHSN), the innovation arm of the ... by providing support to develop and deploy solutions to the most pressing challenges facing ...
(Date:9/30/2019)... THE WOODLANDS, Texas (PRWEB) , ... September 30, ... ... Bridge , the materials science newsletter from Rigaku Corporation , is now ... analysis techniques related to X-ray based materials science, including X-ray diffraction, fluorescence and ...
Breaking Biology Technology:
Cached News: