HOME >> BIOLOGY >> NEWS
Introduction of the 'Rett protein' in post-mitotic neurons rescues Rett Syndrome in mice

Rudolf Jaenisch of the Whitehead Institute of Biomedical Research in Cambridge, MA reports in the April 6, 2004 online issue of the Proceedings of the National Academy of Sciences that introduction of the MeCP2 protein into post-mitotic nerve cells of MeCP2 mutant mice rescues the symptoms of Rett Syndrome. This raises the possibility that neurons are functionally normal in a newborn child and that neural dysfunction manifests itself only later due to prolonged MeCP2 deficiency. If correct, therapeutic strategies aimed at preventing the onset of Rett symptoms could be initiated at birth. This project was funded by the Rett Syndrome Research Foundation (RSRF) and the National Institutes of Health (NIH).

Rett Syndrome (RTT) is a severe neurological disorder diagnosed almost exclusively in girls. Children with RTT appear to develop normally until 6 to 18 months of age, when they enter a period of regression, losing speech and motor skills. Most develop repetitive hand movements, irregular breathing patterns, seizures and extreme motor control problems. RTT leaves its victims profoundly disabled, requiring maximum assistance with every aspect of daily living. There is no cure.

In late 1999 it was discovered that mutations in the gene MECP2 were the leading cause of Rett Syndrome. The gene product, MeCP2, is a protein believed to play a vital role in the regulation of gene expression. It is expressed in all organs and found in especially high levels in the brain. The timing of MeCP2 activation coincides with the maturation of the central nervous system and recent reports suggest that MeCP2 may be involved in the formation of contacts between nerve cells and may function in activity-dependent gene expression (i.e. learning). Multiple labs have shown that selective mutation of MeCP2 in nerve cells after birth leads to Rett-like symptoms in mice, suggesting that MeCP2 plays an important role in mature nerve cells.

Dr. Jaenisch devised an expe
'"/>

Contact: Monica Coenraads
monica@rsrf.org
203-445-9233
Rett Syndrome Research Foundation
7-Apr-2004


Page: 1 2

Related biology news :

1. Effects Of Age Of Introduction Of Complementary Foods On Iron Status OfBreast-Fed Infants In Honduras
2. Optimizing proteins death domain halts leukemia in laboratory study
3. Findings suggest need for new view of p53 cancer proteins interaction with DNA
4. A proteins role in progressive renal disease
5. Rb proteins role in retina development is key to understanding devastating eye cancer
6. Researchers view proteins structural changes in real time
7. Misfolding the key to proteins ability to kill brain cells
8. Researchers solve killer proteins crime
9. Biologists discover proteins impace on plant-water balance
10. Penn researchers proteins link to leukemia
11. New study may explain how fats damage neurons in Alzheimers patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... November 19, 2019 , ... Project Lifeline – a community partnership ... to address substance use disorder (SUD) – will take center stage at ... to the program’s effectiveness in preventing and treating opioid abuse in Blair County, Pennsylvania, ...
(Date:11/14/2019)... ... 2019 , ... NDA Partners Chairman Carl Peck, MD ... program management executive with more than 33 years of regulatory and product development ... an Expert Consultant. , Robert Peterson has extensive experience in formulating and ...
(Date:11/12/2019)... ... November 12, 2019 , ... G5, the leader in ... performance up to 25% and reduces cost-per-click by as much as 15%. An ... attribution (MTA) to predict best advertising outcomes and automatically allocate daily ad investments ...
Breaking Biology News(10 mins):
(Date:10/30/2019)... ... October 30, 2019 , ... Western University of ... innovation and technology play in educating the next generation of health care providers. ... and presentations by WesternU administrators and representatives of companies working with the University ...
(Date:10/26/2019)... ... October 24, 2019 , ... Sparks Marketing ... Group (BMMG), a boutique healthcare-specific marketing firm, to strengthen the agency’s growing ... Strategy Division. , Healthcare clients in pharma, bio-therapeutics, medical device and healthcare technologies ...
(Date:10/22/2019)... ... October 22, 2019 , ... DermBiont, a clinical stage microbiome ... met its primary safety endpoints, with no application site reactions and no adverse ... treatment of interdigital tinea pedis (athlete’s foot). Additionally, the trial demonstrated a clinical ...
(Date:10/10/2019)... (PRWEB) , ... October 09, 2019 , ... ... Amy Abernethy, MD, PhD, Principal Deputy Commissioner, FDA, as a newly-confirmed keynote speaker ... October 2019 in Las Vegas, Nevada USA. , Dr. Abernethy, a hematologist/oncologist and ...
Breaking Biology Technology:
Cached News: