HOME >> BIOLOGY >> NEWS
Introduction of the 'Rett protein' in post-mitotic neurons rescues Rett Syndrome in mice

riment to determine the point at which nerve cells become dysfunctional in "Rett mice". Early in embryonic development precursor neuronal cells divide rapidly. As the brain cells mature they stop dividing and become post-mitotic. Dr. Jaenisch hooked the MECP2 gene to the Tau gene which is expressed only in post-mitotic neurons. Mutant Mecp2 mice that also expressed the Tau/Mecp2 transgene never manifested any of the Rett-like symptoms and developed normally.

The experiments also showed that introducing too much MeCP2, 4-6 fold, caused severe motor deficits. This will be an important issue as treatments are developed.

"These experiments lay the groundwork for the next key project: determining whether Rett Syndrome is reversible and if so identifying the appropriate time frame for MeCP2 re-introduction." shared Dr. Jaenisch.

"The announcement by Dr. Jaenisch and his colleagues is an important step towards realizing our mission of accelerating treatments and cures for Rett Syndrome. RSRF has financially supported Dr. Jaenisch's work since our inception and we are encouraged by the contributions he is making to the field", stated Gordy Rich, Chairman of the RSRF Board of Trustees.


'"/>

Contact: Monica Coenraads
monica@rsrf.org
203-445-9233
Rett Syndrome Research Foundation
7-Apr-2004


Page: 1 2

Related biology news :

1. Effects Of Age Of Introduction Of Complementary Foods On Iron Status OfBreast-Fed Infants In Honduras
2. Optimizing proteins death domain halts leukemia in laboratory study
3. Findings suggest need for new view of p53 cancer proteins interaction with DNA
4. A proteins role in progressive renal disease
5. Rb proteins role in retina development is key to understanding devastating eye cancer
6. Researchers view proteins structural changes in real time
7. Misfolding the key to proteins ability to kill brain cells
8. Researchers solve killer proteins crime
9. Biologists discover proteins impace on plant-water balance
10. Penn researchers proteins link to leukemia
11. New study may explain how fats damage neurons in Alzheimers patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... 2019 , ... Rigaku Corporation , a global leader ... & Microanalysis 2019 Meeting ( M&M 2019 ), taking place August 4 - ... & Microanalysis Meeting, organized by the Microscopy Society of America, is the world’s ...
(Date:8/1/2019)... CAMBRIDGE, Mass. (PRWEB) , ... August 01, 2019 , ... ... announced by Johannes Fruehauf, MD, PhD, founder and president of BioLabs, which provides premier ... created the CFO role to strengthen our ability to forecast and manage growth,” says ...
(Date:7/26/2019)... ... July 26, 2019 , ... Worldwide Business ... Medical Technologies CEO Phil Deschamps to discuss their potential new treatment option to ... is a neurotech company in the medical device industry that's focused on neurological ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... ... 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , ... The film focuses on regenerative veterinary medicine as a means of improving the ... included in the Brentwood and Pacific Palisades International Film Festival in Los Angeles, ...
(Date:6/18/2019)... Calif. (PRWEB) , ... June 18, 2019 , ... ... an Investigational New Drug (IND) application to the FDA for use of a person’s ... cells as a treatment of osteoarthritis in the knee. This IND is the ...
(Date:6/11/2019)... ... June 10, 2019 , ... Advancements ... an upcoming episode, scheduled to broadcast 4Q/2019. Check your local listings for more ... educate viewers about how its technology facilitates laboratories to improve efficiency and quality ...
(Date:6/11/2019)... ... June 11, 2019 , ... Veterinary Regenerative Medicine ... (PSC) , has announced that their GMP facility for cell production is now ... manufacturing. This is an important milestone for VetStem as it expands into ...
Breaking Biology Technology:
Cached News: