HOME >> BIOLOGY >> NEWS
Is there a common genetic link for depression and cardiovascular disease?

A large body of evidence has emerged over several years for an association between depressive disorder and cardiovascular disease. Although many studies have shown that depression increases the risk for coronary artery disease and the mortality rates after myocardial infarction, there is recent support for the assumption that the relation between both disorders may be bi-directional. The mechanisms of this interaction are at present uncertain and several factors, including stress with its multiple actions on brain and peripheral organs, acute inflammatory reactions with altered immune function as well as a genetically driven susceptibility to develop the disorders are under debate.

Regarding the genetic contribution, variants in two genes were repeatedly discussed as important predisposing factor for cardiovascular function and disease. The gene coding for the angiotensin-converting-enzyme (ACE), an enzyme which is involved in the development of hypertension and other cardiovascular distress, has a common mutation (allele-D) which results in increased ACE concentration (consequently, ACE inhibitors are used as antihypertensive agents). Several studies have shown an association between this allele-D and cardiovascular disorders, supporting the hypothesis of a genetic contribution. However, not only the actual concentration of ACE but also other factors are relevant for cardiovascular function and the development of diseases. Among those is the transduction of nervous signals, which is regulated by various components, including G-proteins. G-proteins are located within the cellular membranes and are thus key elements for the signal transduction, as they induce a cascade of cell reactions after the incoming signal. Thus alterations in the function of these G-proteins could have tremendous effects upon rapidity and quality of the nervous signal transmission. And recently a mutation in one subtype of these G-protein genes, the G-3 subunit allele-T was observed n
'"/>

Contact: Aimee Midei
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
9-Dec-2002


Page: 1 2 3

Related biology news :

1. Waiter, theres a shark in my soup
2. Is there a benefit to having been vaccinated against smallpox as a child?
3. Is there an unexpected price for late night high tech excitement?
4. Just how many species are there, anyway?
5. Rainforests at risk: Where theres smoke, theres even more fire
6. Is there a link between soy formula and attention deficit disorder?
7. The nanoscience of wood structure Nature was there first
8. Where theres fire
9. The new biology of rocks: Are there medical implications of geomicrobiology?
10. Is there a link between alcohol and allergies?
11. Is there a protective gene against alcoholism?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2019)... (PRWEB) , ... February 26, 2019 , ... ... since 2018. In her position as Account Manager, Ms. Baptiste demonstrated her ability ... overall customer experience. Ms. Baptiste was responsible for partnering with both the Strategic ...
(Date:2/22/2019)... , ... February 20, 2019 , ... ... devices and precision medicine, the traditional line between engineering and medical science grows ... faster and smarter, the medical device industry is making medical practice easier for ...
(Date:2/22/2019)... SAN ANTONIO (PRWEB) , ... February 21, 2019 , ... ... at the 54th annual meeting of the Texas Society for Microscopy ( TSM ). ... Texas in San Antonio and takes place February 21st - 23rd, 2019. Several workshops ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... March 19, 2019 , ... Cirrascale Cloud ... it has begun offering NVIDIA® DGX-1™ deep learning systems as part of its ... provide the highest performance for artificial intelligence and deep learning research and development. ...
(Date:3/14/2019)... ... March 14, 2019 , ... Open registration for the Case ... Spectrum of Case Management,” continues as CMSA makes plans to host the annual ... case management industry conference serving the educational and networking needs of case and ...
(Date:3/12/2019)... Colo. (PRWEB) , ... March 11, 2019 , ... ... the first hospital system in Colorado, and among the first in the nation, ... scores around lab draws, IV placement and overall degree to which staff showed ...
(Date:3/9/2019)... SEATTLE (PRWEB) , ... March ... ... source for unbiased college rankings and higher education planning, announced the release ... identifies the top programs in the nation based on curriculum quality, program ...
Breaking Biology Technology:
Cached News: