Regarding the genetic contribution, variants in two genes were repeatedly discussed as important predisposing factor for cardiovascular function and disease. The gene coding for the angiotensin-converting-enzyme (ACE), an enzyme which is involved in the development of hypertension and other cardiovascular distress, has a common mutation (allele-D) which results in increased ACE concentration (consequently, ACE inhibitors are used as antihypertensive agents). Several studies have shown an association between this allele-D and cardiovascular disorders, supporting the hypothesis of a genetic contribution. However, not only the actual concentration of ACE but also other factors are relevant for cardiovascular function and the development of diseases. Among those is the transduction of nervous signals, which is regulated by various components, including G-proteins. G-proteins are located within the cellular membranes and are thus key elements for the signal transduction, as they induce a cascade of cell reactions after the incoming signal. Thus alterations in the function of these G-proteins could have tremendous effects upon rapidity and quality of the nervous signal transmission. And recently a mutation in one subtype of these G-protein genes, the G-3 subunit allele-T was observed n
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Contact: Aimee Midei
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
9-Dec-2002