Islet cell transplantation for diabetes turns corner

MIAMI, Aug. 27 More diabetic patients are coming off insulin following pancreatic islet cell transplantation than ever before, according to multiple studies presented today at the XIX International Congress of The Transplantation Society being held through Aug. 30 at the Westin Diplomat Resort and Spa in Hollywood, Fla. One report of new international data shows 80 percent of patients are remaining insulin free one year after receiving infusions of the insulin-producing cells, a success rate that is on a par with whole pancreas transplantation and markedly improved over the 14 percent rate reported for 1998-2000.

One-year, insulin-free status also was achieved in a child who received a mixture of pig cells, without the use of immunosuppressive drugs and without her immune system attacking the animal cells, reported Dr. Rafael Valdes from the Children's Hospital of Mexico and colleagues from the University of Western Ontario and Diatranz, Ltd., of New Zealand. A second child of the 12 in the study was off insulin for six months and currently requires 75 percent less insulin than before the transplant.

The mixture of cells consisted of islet cells and testicular Sertoli cells taken from neonatal pigs. Sertoli cells are thought to have a special ability to subdue immune system T cells, which normally fight against the presence of anything foreign. The researchers gave the cells to 12 children with type 1 diabetes between the ages of 11 and 17 and did not administer any immunosuppressive drugs to protect the cells from being rejected. Six of the 12 patients have functioning grafts, and subsequent to receiving additional transplanted islets at 20 weeks, they have demonstrated improvements in their islet function.

According to the researchers, the pig cells did not elicit the expected immune system response in the patients, and retransplantation of islets failed to stimulate a secondary response against the pig cells as well.


Contact: Lisa Rossi
Transplantation Society

Page: 1 2 3 4

Related biology news :

1. Islet cells from swine reverse insulin dependency in diabetic non-human primates
2. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
3. Pig-human transplantation not PERVerted
4. Cells from adult bone marrow can be converted into brain stem cells for transplantation
5. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
6. Hopkins researchers identify transplantation antigens among Sioux Indians
7. Transparent fish provide window on blood formation and marrow transplantation
8. Immerge BioTherapeutics announces new findings addressing key safety risk in xenotransplantation
9. Cell transplantation could restore cardiac function after heart attack
10. Prize to Weizmann Institute professor for landmark work in stem cell transplantation
11. 1st evidence that nuclear transplantation (therapeutic cloning) can eliminate tissue rejection

Post Your Comments:

(Date:8/12/2020)... Mich. (PRWEB) , ... August 11, 2020 , ... ... R&D subsidiary based in Princeton, NJ, have entered into license agreements with Housey ... and development. Both Roche and J&J have annual Research and Development spending ...
(Date:8/5/2020)... ... 2020 , ... Regenative Labs has received approval from the Centers for Medicare ... the first Wharton’s jelly allografts to be assigned a Q code and be approved ... first Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS ...
(Date:7/22/2020)... BARBARA, Calif. (PRWEB) , ... July 21, 2020 ... ... firm driving digital transformation and innovation in technology and compliance, announces a new ... medical device companies must ensure every layer of their technology stack complies with ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... ... biotechnology, and diagnostics companies, has announced the placement of Julianne Averill , ... responsible for leading all financial operations and implementing key business strategies to accelerate ...
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the leading platform ... Advisory Board (SAB) to research the medical potential of terpenes and the potential ... with terpenes. The board is focused on expanding the recently launched line of effects-based ...
(Date:8/12/2020)... ... 11, 2020 , ... The FSHD Society announced today that ... Clinical Trial Research Network (FSHD CTRN), with consideration of follow-on funding of ... academic research centers in the United States and Europe with expertise in FSHD ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... International), a global leader in FDA compliance consulting has been named on its ... companies. The list represents a unique look at the most successful companies within ...
Breaking Biology Technology:
Cached News: