HOME >> BIOLOGY >> NEWS
Islet cell transplantation for diabetes turns corner

MIAMI, Aug. 27 More diabetic patients are coming off insulin following pancreatic islet cell transplantation than ever before, according to multiple studies presented today at the XIX International Congress of The Transplantation Society being held through Aug. 30 at the Westin Diplomat Resort and Spa in Hollywood, Fla. One report of new international data shows 80 percent of patients are remaining insulin free one year after receiving infusions of the insulin-producing cells, a success rate that is on a par with whole pancreas transplantation and markedly improved over the 14 percent rate reported for 1998-2000.

One-year, insulin-free status also was achieved in a child who received a mixture of pig cells, without the use of immunosuppressive drugs and without her immune system attacking the animal cells, reported Dr. Rafael Valdes from the Children's Hospital of Mexico and colleagues from the University of Western Ontario and Diatranz, Ltd., of New Zealand. A second child of the 12 in the study was off insulin for six months and currently requires 75 percent less insulin than before the transplant.

The mixture of cells consisted of islet cells and testicular Sertoli cells taken from neonatal pigs. Sertoli cells are thought to have a special ability to subdue immune system T cells, which normally fight against the presence of anything foreign. The researchers gave the cells to 12 children with type 1 diabetes between the ages of 11 and 17 and did not administer any immunosuppressive drugs to protect the cells from being rejected. Six of the 12 patients have functioning grafts, and subsequent to receiving additional transplanted islets at 20 weeks, they have demonstrated improvements in their islet function.

According to the researchers, the pig cells did not elicit the expected immune system response in the patients, and retransplantation of islets failed to stimulate a secondary response against the pig cells as well.

"Whether
'"/>

Contact: Lisa Rossi
press@txmiami2002.com
412-916-3315
Transplantation Society
27-Aug-2002


Page: 1 2 3 4

Related biology news :

1. Islet cells from swine reverse insulin dependency in diabetic non-human primates
2. New fruitfly model of diabetes has future implications for pancreatic cell transplantation
3. Pig-human transplantation not PERVerted
4. Cells from adult bone marrow can be converted into brain stem cells for transplantation
5. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
6. Hopkins researchers identify transplantation antigens among Sioux Indians
7. Transparent fish provide window on blood formation and marrow transplantation
8. Immerge BioTherapeutics announces new findings addressing key safety risk in xenotransplantation
9. Cell transplantation could restore cardiac function after heart attack
10. Prize to Weizmann Institute professor for landmark work in stem cell transplantation
11. 1st evidence that nuclear transplantation (therapeutic cloning) can eliminate tissue rejection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... ... July 21, 2020 , ... USDM Life Sciences ... compliance, announces a new solution to manage regulated workloads on Microsoft Azure. , ... technology stack complies with FDA and global regulations. USDM's new managed service for ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability ... Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, ... is the most effective way to complete one? Will the study comply with ...
(Date:7/2/2020)... ... July 01, 2020 , ... ... 1a findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host ... by hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader ... tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at a time ... track capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical ...
(Date:7/31/2020)... TORONTO (PRWEB) , ... July 29, 2020 , ... eSource ... and inefficiencies. This webinar will cover the history of eSource, the reasons it did ... From EMR/EHR to wearables, to site source, the industry is moving towards capturing data ...
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 16, 2020 , ... After ... begins. The completion of a great surgery is only the beginning of a successful ... the research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/10/2020)... ... July 08, 2020 , ... Bode Technology, ... of laboratory operations through its COVID-19 testing service, Bode-CARES . Bode-CARES combines ... Bode-CARES provides a turnkey solution that includes a comprehensive collection and ...
Breaking Biology Technology:
Cached News: