Islet cells from swine reverse insulin dependency in diabetic non-human primates

June 3, 2003 Washington, DC: Today at the American Transplant Congress, Martin N Wijkstrom, M.D., on behalf of researchers from the Diabetes Institute for Immunology and Transplantation, Department of Surgery at the University of Minnesota and Immerge BioTherapeutics, Inc., presented data showing reversal of diabetes in monkeys after transplantation with porcine islet cells. Immediately post-transplant, each of the monkeys no longer required insulin and achieved normal glucose levels. Researchers used combinations of immunosuppressive therapies to allow the cells to function within the primates for more than 70 days.

"This data is very significant because while we have been able to reverse diabetes in past islet studies, we had only seen 2-3 week survival times before the graft was lost due to the overwhelming rejection response," said Professor Bernhard Hering, M.D., Associate Director of the Diabetes Institute for Immunology and Transplantation at the University of Minnesota. "For this study, we looked at immunosuppressive regimens that were well tolerated in past monkey-to-monkey islet transplants. The survival times we are reporting on today should only increase as we further optimize the immunosuppressive regimens."

In this study, diabetic cynomolgus monkeys were transplanted with islets purified from the pancreas of adult pigs or miniature swine. They were then treated with an immunosuppressive cocktail, including induction and maintenance therapy. All animals became insulin independent and reached normal glucose levels in the period after transplantation, and a number of animals were insulin-free for up to 70 days after transplantation.

"None of the animals showed evidence of antibody-mediated rejection, which is a major type of rejection for solid organs like kidneys and heart" said Henk-Jan Schuurman, Ph.D., Vice President Research at Immerge BioTherapeutics, Inc. "The immune rejection responses we did observe were T-cell

Contact: Susan Hayes
S. Hayes Consulting

Page: 1 2

Related biology news :

1. Islet cell transplantation for diabetes turns corner
2. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
3. Researchers develop fast track way to discover how cells are regulated
4. Chemical signals health of brain cells Symposium
5. New dye directly reveals activated proteins in living cells
6. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
7. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
8. Smac-ing back at cancer cells
9. Bone marrow cells routinely help with wound healing
10. Genuine stem cells found in skin might treat hair loss, wounds
11. Skin stem cells give hairless mice hair

Post Your Comments:

(Date:8/14/2019)... ... August 14, 2019 , ... Representatives with MyBioGate announced that China Focus@Biotech Week ... , “We help innovative projects connect with Chinese pharma and investors in healthcare innovation,” ... on to explain that as a part of Biotech Week Boston – the annual ...
(Date:8/14/2019)... ... ... Julie Reck of Veterinary Medical Center of Fort Mill has recently begun providing ... her own geriatric Australian Shepherd, Simon, was treated in June 2019 for osteoarthritis in his ... body was weak, and he struggled to play fetch and other games with his family. ...
(Date:8/6/2019)... ... August 06, 2019 , ... VetStem Biopharma ... and GMP manufacturing experience. In November it spun out a human regenerative ... experience and one of the first cGMP cell manufacturing facilities in California ...
Breaking Biology News(10 mins):
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc (“PSC”), a ... the FDA for use of a person’s own adipose-derived stem cells to treat their ... the knee. This IND is the first of several planned clinical trials which ...
(Date:6/11/2019)... ... June 10, 2019 , ... Thought Technology Ltd is pleased ... Biofeedback Tech Ltd as its authorised distributor for the UK and ... therapeutic treatments and clinical assessment protocols to treat stress related disorders as well ...
(Date:6/11/2019)... ... June 10, 2019 , ... ... add 80 of its scientific journals to DeepDyve’s rental service for peer-reviewed journals. ... continually expanding library of more than 20 million articles, sourced from more than ...
(Date:6/11/2019)... ... June 11, 2019 , ... Veterinary Regenerative ... Inc. (PSC) , has announced that their GMP facility for cell production is ... for manufacturing. This is an important milestone for VetStem as it expands ...
Breaking Biology Technology:
Cached News: