HOME >> BIOLOGY >> NEWS
Islet cells from swine reverse insulin dependency in diabetic non-human primates

June 3, 2003 Washington, DC: Today at the American Transplant Congress, Martin N Wijkstrom, M.D., on behalf of researchers from the Diabetes Institute for Immunology and Transplantation, Department of Surgery at the University of Minnesota and Immerge BioTherapeutics, Inc., presented data showing reversal of diabetes in monkeys after transplantation with porcine islet cells. Immediately post-transplant, each of the monkeys no longer required insulin and achieved normal glucose levels. Researchers used combinations of immunosuppressive therapies to allow the cells to function within the primates for more than 70 days.

"This data is very significant because while we have been able to reverse diabetes in past islet studies, we had only seen 2-3 week survival times before the graft was lost due to the overwhelming rejection response," said Professor Bernhard Hering, M.D., Associate Director of the Diabetes Institute for Immunology and Transplantation at the University of Minnesota. "For this study, we looked at immunosuppressive regimens that were well tolerated in past monkey-to-monkey islet transplants. The survival times we are reporting on today should only increase as we further optimize the immunosuppressive regimens."

In this study, diabetic cynomolgus monkeys were transplanted with islets purified from the pancreas of adult pigs or miniature swine. They were then treated with an immunosuppressive cocktail, including induction and maintenance therapy. All animals became insulin independent and reached normal glucose levels in the period after transplantation, and a number of animals were insulin-free for up to 70 days after transplantation.

"None of the animals showed evidence of antibody-mediated rejection, which is a major type of rejection for solid organs like kidneys and heart" said Henk-Jan Schuurman, Ph.D., Vice President Research at Immerge BioTherapeutics, Inc. "The immune rejection responses we did observe were T-cell
'"/>

Contact: Susan Hayes
shayesconsult@earthlink.net
212-533-4472
S. Hayes Consulting
3-Jun-2003


Page: 1 2

Related biology news :

1. Islet cell transplantation for diabetes turns corner
2. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
3. Researchers develop fast track way to discover how cells are regulated
4. Chemical signals health of brain cells Symposium
5. New dye directly reveals activated proteins in living cells
6. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
7. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
8. Smac-ing back at cancer cells
9. Bone marrow cells routinely help with wound healing
10. Genuine stem cells found in skin might treat hair loss, wounds
11. Skin stem cells give hairless mice hair

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2019)... , ... April 04, 2019 , ... ... with integrated linear encoders providing 0.05 microns and 0.005 microns resolution, respectively. The ... and drive variations are available, from fast DC-servo motors with linear encoders and ...
(Date:4/4/2019)... ... April 02, 2019 , ... The live session ... into the connectivity between product risk management (ISO 14971) and the clinical risk ... process. , With increasing global regulation and reimbursement challenges faced by medical device ...
(Date:4/1/2019)... (PRWEB) , ... April 01, 2019 , ... ... and System for Characterizing Skin Related Conditions” by the US Patent and Trademark ... The patent is an invention by uBiome collaborators Dr. Zachary Apte, Dr. ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... April 09, 2019 , ... Sonny Bar Lisa, or Sonny ... for approximately two months. After a series of diagnostics, an MRI was performed ... owner, Alison, researched the injury and found that VetStem Regenerative Cell Therapy ...
(Date:4/8/2019)... ... April 08, 2019 , ... US Capital Global ... $15 million preferred equity investment in the privately held pharmaceutical company, S1 Biopharma (“S1”). ... Lorexys, is targeted at female hypoactive sexual dysfunction disorder and is ready to begin ...
(Date:4/4/2019)... (PRWEB) , ... April 03, 2019 , ... ... together through intimate off-the-record collaboration and dialogue, today announces its Boston CEO conference ... offers insights into the industry’s challenges and opportunities with high-level panels and discussions ...
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, ... importance of healthy meals and good nutrition. This month, Chef Jodi Abel appeared ... chef. , The first segment addressed the nutritional value of USDA’s MyPlate, ...
Breaking Biology Technology:
Cached News: